Clinicogenomic analysis of EGFR-mutant lung tumors identifies Rb pathway inactivation as a hallmark of squamous transformation.
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| Title: | Clinicogenomic analysis of EGFR-mutant lung tumors identifies Rb pathway inactivation as a hallmark of squamous transformation. |
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| Authors: | Dymun A; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Jeng MY; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Elkrief A; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Mehrotra H; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Yang SR; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Wilson C; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Rekhtman N; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Linkov I; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Pupo A; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Falcon C; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Wilhelm CJ; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Manoj P; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Zhong H; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Sridhar H; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Kris MG; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA., Socci ND; Bioinformatics Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Qiu J; Antitumor Assessment Core Facility, Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., de Stanchina E; Antitumor Assessment Core Facility, Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Richards AL; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Donoghue MTA; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Rudin CM; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA., Yu HA; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA., Quintanal-Villalonga Á; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2026 Jun 17; Vol. 18 (854), pp. eaea4881. Date of Electronic Publication: 2026 Jun 17. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.aea4881 |
