Targeting N1-methyladenosine modification in osteoblasts through tRNA methyltransferase 10C reverses mitochondrial dysfunction and ameliorates osteoporosis.
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| Title: | Targeting N1-methyladenosine modification in osteoblasts through tRNA methyltransferase 10C reverses mitochondrial dysfunction and ameliorates osteoporosis. |
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| Authors: | Sun H; Department of Orthopedics, The Second Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China., Wang W; Department of Orthopedics, The Second Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China., Zhang C; Department of Orthopedics, The Second Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China., Zhang T; Department of Orthopedics, The Second Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China., Yang X; Department of Infectious Diseases and Liver Diseases, Ningbo Medical Center Lihuili Hospital, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, China., Feng Y; Department of Orthopedics, The Second Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China., Shan L; Department of Blood Transfusion, First Affiliated Hospital of Nanchang University, Jiangxi Key Laboratory of Transfusion, Institute of Transfusion, Jiangxi Academy of Clinical Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, China., Yang Z; Department of Basic Medicine, Cangzhou Medical College, Cangzhou, China., Zhang Y; Department of Medicinal Chemistry, State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China., Liu S; Department of Orthopedics, The Second Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China. xinying5475@sina.com., Wang W; Department of Orthopedics, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China. wayne1898@163.com., Wang J; Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, China. wangjc@sdu.edu.cn., Hou X; Department of Medicinal Chemistry, State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. hxb@sdu.edu.cn., Feng S; Department of Orthopedics, The Second Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China. shiqingfeng@sdu.edu.cn.; Department of Orthopedics, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China. shiqingfeng@sdu.edu.cn.; Shandong University Centre for Orthopedics, Shandong Key Laboratory of Integrated Bioengineering, Cheeloo College of Medicine, Shandong University, Jinan, China. shiqingfeng@sdu.edu.cn. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jun 18; Vol. 11 (1). Date of Electronic Publication: 2026 Jun 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2059-3635 |
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| DOI: | 10.1038/s41392-026-02740-2 |
