Genetic variation at the IL-18-137C>G is associated with poor sepsis prognosis and enhanced inflammatory responses: a multicenter hospital-based study.

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Title: Genetic variation at the IL-18-137C>G is associated with poor sepsis prognosis and enhanced inflammatory responses: a multicenter hospital-based study.
Authors: Li Z; Jinan University, Guangzhou, Guangdong, China.; The Intensive Care Unit, The Second Affiliated Hospital, Guangdong Medical University, Zhanjiang, Guangdong, China., Gu W; Jinan University, Guangzhou, Guangdong, China., Liu L; The Intensive Care Unit, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, China.; The Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China., Li J; The Intensive Care Unit, Jieyang People's Hospital, Jieyang, Guangdong, China., Zhang M; The Intensive Care Unit, Jieyang People's Hospital, Jieyang, Guangdong, China., Yang W; The Intensive Care Unit, Jieyang People's Hospital, Jieyang, Guangdong, China., Yang M; The Intensive Care Unit, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, China., Zhang J; The Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.; The Intensive Care Unit, Jieyang People's Hospital, Jieyang, Guangdong, China., Zhong H; The Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.; The Intensive Care Unit, Jieyang People's Hospital, Jieyang, Guangdong, China., Liu Y; The Intensive Care Unit, Jieyang People's Hospital, Jieyang, Guangdong, China., He J; The Intensive Care Unit, Jieyang People's Hospital, Jieyang, Guangdong, China., Yin H; Jinan University, Guangzhou, Guangdong, China., Shao Y; Jinan University, Guangzhou, Guangdong, China.; The Intensive Care Unit, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, China.; The Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Source: Frontiers in genetics [Front Genet] 2026 Jun 03; Vol. 17, pp. 1820930. Date of Electronic Publication: 2026 Jun 03 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101560621 Publication Model: eCollection Cited Medium: Print ISSN: 1664-8021 (Print) Linking ISSN: 16648021 NLM ISO Abbreviation: Front Genet Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:1664-8021
DOI:10.3389/fgene.2026.1820930