Dual CDK2 and CDK4/6 inhibition suppresses Rb/E2F signaling and enhances anti-leukemic activity in acute myeloid leukemia.

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Title: Dual CDK2 and CDK4/6 inhibition suppresses Rb/E2F signaling and enhances anti-leukemic activity in acute myeloid leukemia.
Authors: Weisberg E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA. ellen_weisberg@dfci.harvard.edu., Chowdhury B; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA., Garg S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Department of Molecular Genetics, Erasmus Medical Center, Rotterdam., Akatsu T; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Ni W; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA., Gokhale PC; Experimental Therapeutics Core, Dana-Farber Cancer Institute, Boston, MA., Eschle BK; Experimental Therapeutics Core, Dana-Farber Cancer Institute, Boston, MA., Grant S; Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA., Sattler M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA., DeCaprio JA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA., Nöltner L; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Molecular Oncology, Faculty of Medicine, University of Leipzig, Leipzig, Germany., Garcia J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA., Marinchev K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Galinsky I; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Nath A; Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA., Stone RM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA., Griffin JD; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA.
Source: Haematologica [Haematologica] 2026 Jun 18. Date of Electronic Publication: 2026 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1592-8721
DOI:10.3324/haematol.2026.300728