Letrozole and Infertility Among Males With Spermatogenic Failure: A Randomized Clinical Trial.
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| Title: | Letrozole and Infertility Among Males With Spermatogenic Failure: A Randomized Clinical Trial. |
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| Authors: | Sun Y; Department of Andrology, the Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Yao C; Department of Andrology, the Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Liu G; Department of Andrology, The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China., Li Z; Department of Andrology, The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China., Yang X; State Key Laboratory of Reproductive Medicine and Offspring Health, Clinical Center of Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Chen Q; Department of Andrology, The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China., Ye Z; Center for Reproductive Medicine, Wuhan Children's Hospital: Wuhan Women and Children Medical Care Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Wuhan Huake Reproductive Hospital, Wuhan, Hubei, China., Li H; Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China., Qu X; Reproductive Medicine Center, Henan Provincial People's Hospital, Zhengzhou, Henan, China.; Reproductive Medicine Center, Zhengzhou University People's Hospital, Zhengzhou, Henan, China.; Henan Joint International Research Laboratory of Reproductive Bioengineering, Zhengzhou, Henan, China., Guo H; Reproductive Medicine Center, Henan Provincial People's Hospital, Zhengzhou, Henan, China.; Reproductive Medicine Center, Zhengzhou University People's Hospital, Zhengzhou, Henan, China.; Henan Joint International Research Laboratory of Reproductive Bioengineering, Zhengzhou, Henan, China., Yang J; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China., Wang T; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China., Liang G; Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China., Zhu X; Department of Gynecology and Obstetrics, Reproductive Medical Center, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Lu Y; Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, Hunan, China., Chen W; Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Zhang F; Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Tian R; Department of Andrology, the Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhi E; Department of Andrology, the Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Chen H; Department of Andrology, the Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhao F; Department of Andrology, the Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Bai F; Department of Andrology, the Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Sun H; Department of Andrology, the Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhang J; Department of Andrology, the Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Bu X; Taizhou School of Clinical Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu, China., Qian D; Taizhou School of Clinical Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu, China., Wu S; Clinical Research Unit, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Qiu Y; Clinical Research Unit, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Li Z; Department of Andrology, the Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Taizhou School of Clinical Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu, China., Li P; Department of Andrology, the Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. |
| Source: | JAMA network open [JAMA Netw Open] 2026 Jun 01; Vol. 9 (6), pp. e2618422. Date of Electronic Publication: 2026 Jun 01. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Multicenter Study |
| Journal Info: | Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2574-3805 |
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| DOI: | 10.1001/jamanetworkopen.2026.18422 |
