ABO: A 3D stroma-supported culture platform enabling full human B-lymphopoiesis for disease modeling and gene therapy development.

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Title: ABO: A 3D stroma-supported culture platform enabling full human B-lymphopoiesis for disease modeling and gene therapy development.
Authors: Braams M; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden, the Netherlands., Cordes M; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; Department of Pediatrics, Leiden University Medical Center, 2300RC Leiden, the Netherlands., Vloemans SA; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands., de Mooij B; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands., de Bruin-Versteeg S; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands., Wachtmeester A; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands., Langerak AW; Department of Immunology, Laboratory Medical Immunology, Erasmus Medical Center, University Medical Center Rotterdam, 3015GD Rotterdam, the Netherlands., Pike-Overzet K; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands., Staal FJT; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden, the Netherlands; Department of Pediatrics, Leiden University Medical Center, 2300RC Leiden, the Netherlands. Electronic address: f.j.t.staal@lumc.nl., Canté-Barrett K; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: k.cante@lumc.nl., de Kivit S; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: s.de_kivit@lumc.nl.
Source: Cell reports. Medicine [Cell Rep Med] 2026 Jun 18, pp. 102879. Date of Electronic Publication: 2026 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Braams+M%22">Braams M</searchLink>; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Cordes+M%22">Cordes M</searchLink>; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; Department of Pediatrics, Leiden University Medical Center, 2300RC Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Vloemans+SA%22">Vloemans SA</searchLink>; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Mooij+B%22">de Mooij B</searchLink>; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Bruin-Versteeg+S%22">de Bruin-Versteeg S</searchLink>; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wachtmeester+A%22">Wachtmeester A</searchLink>; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Langerak+AW%22">Langerak AW</searchLink>; Department of Immunology, Laboratory Medical Immunology, Erasmus Medical Center, University Medical Center Rotterdam, 3015GD Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Pike-Overzet+K%22">Pike-Overzet K</searchLink>; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Staal+FJT%22">Staal FJT</searchLink>; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden, the Netherlands; Department of Pediatrics, Leiden University Medical Center, 2300RC Leiden, the Netherlands. Electronic address: f.j.t.staal@lumc.nl.<br /><searchLink fieldCode="AU" term="%22Canté-Barrett+K%22">Canté-Barrett K</searchLink>; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: k.cante@lumc.nl.<br /><searchLink fieldCode="AU" term="%22de+Kivit+S%22">de Kivit S</searchLink>; Department of Immunology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: s.de_kivit@lumc.nl.
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  Data: <searchLink fieldCode="JN" term="%22101766894%22">Cell reports. Medicine</searchLink> [Cell Rep Med] 2026 Jun 18, pp. 102879. <i>Date of Electronic Publication: </i>2026 Jun 18.
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              Text: 2026 Jun 18
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