Saligenin restores insulin responsiveness in lipotoxic myotubes through L-cell-derived GLP-1 via ER stress-autophagy modulation.

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Title: Saligenin restores insulin responsiveness in lipotoxic myotubes through L-cell-derived GLP-1 via ER stress-autophagy modulation.
Authors: Lim DS; Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea., Park SK; Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, Republic of Korea., Pyo MK; Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, Republic of Korea., Ko JH; Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, Republic of Korea., Abd El-Aty AM; Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt; Department of Medical Pharmacology, Medical Faculty, Ataturk University, Erzurum 25240, Turkey. Electronic address: abdelaty44@hotmail.com., Jeong JH; Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, Republic of Korea., Lee KT; Department of Forest Bioresources, Division of Forest Microbiology, National Institute of Forest Science, Suwon 16631, Republic of Korea. Electronic address: leekt99@korea.com., Jung TW; Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea. Electronic address: twjung@cau.ac.kr.
Source: Tissue & cell [Tissue Cell] 2026 Jun 17; Vol. 103, pp. 103704. Date of Electronic Publication: 2026 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1532-3072
DOI:10.1016/j.tice.2026.103704