Dual engagement of Spike and ACE2 by annexin A5 contributes to pleiotropic SARS-CoV-2 inhibition.

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Title: Dual engagement of Spike and ACE2 by annexin A5 contributes to pleiotropic SARS-CoV-2 inhibition.
Authors: Chandrabalan A; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada.; Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada., Lin QT; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada., Fariha KA; Department of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada., Solis-Reyes P; Department of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada., Richer CG; Department of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada., Troyer RM; Department of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada. rtroyer@uwo.ca., Barr SD; Department of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada. sbarr9@uwo.ca., Feng Q; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada. qfeng@uwo.ca., Stathopulos PB; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada. pstatho@uwo.ca.
Source: Scientific reports [Sci Rep] 2026 Jun 20. Date of Electronic Publication: 2026 Jun 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2045-2322
DOI:10.1038/s41598-026-58451-9