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Dual engagement of Spike and ACE2 by annexin A5 contributes to pleiotropic SARS-CoV-2 inhibition.

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Title: Dual engagement of Spike and ACE2 by annexin A5 contributes to pleiotropic SARS-CoV-2 inhibition.
Authors: Chandrabalan A; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada.; Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada., Lin QT; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada., Fariha KA; Department of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada., Solis-Reyes P; Department of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada., Richer CG; Department of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada., Troyer RM; Department of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada. rtroyer@uwo.ca., Barr SD; Department of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada. sbarr9@uwo.ca., Feng Q; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada. qfeng@uwo.ca., Stathopulos PB; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada. pstatho@uwo.ca.
Source: Scientific reports [Sci Rep] 2026 Jun 20. Date of Electronic Publication: 2026 Jun 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dual engagement of Spike and ACE2 by annexin A5 contributes to pleiotropic SARS-CoV-2 inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Chandrabalan+A%22">Chandrabalan A</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada.; Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lin+QT%22">Lin QT</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada.<br /><searchLink fieldCode="AU" term="%22Fariha+KA%22">Fariha KA</searchLink>; Department of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada.<br /><searchLink fieldCode="AU" term="%22Solis-Reyes+P%22">Solis-Reyes P</searchLink>; Department of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada.<br /><searchLink fieldCode="AU" term="%22Richer+CG%22">Richer CG</searchLink>; Department of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada.<br /><searchLink fieldCode="AU" term="%22Troyer+RM%22">Troyer RM</searchLink>; Department of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada. rtroyer@uwo.ca.<br /><searchLink fieldCode="AU" term="%22Barr+SD%22">Barr SD</searchLink>; Department of Microbiology & Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada. sbarr9@uwo.ca.<br /><searchLink fieldCode="AU" term="%22Feng+Q%22">Feng Q</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada. qfeng@uwo.ca.<br /><searchLink fieldCode="AU" term="%22Stathopulos+PB%22">Stathopulos PB</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada. pstatho@uwo.ca.
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        Value: 10.1038/s41598-026-58451-9
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              Text: 2026 Jun 20
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