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Smoking-associated modulation of gut microbiota shapes response to immune checkpoint inhibitors in non-small cell lung cancer.

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Title: Smoking-associated modulation of gut microbiota shapes response to immune checkpoint inhibitors in non-small cell lung cancer.
Authors: Chien PY; Department of Pharmacy, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC.; Department of Pharmacy, China Medical University, No. 100, Sec. 1, Jingmao Rd., Beitun Dist., Taichung, 406040, Taiwan, ROC., Cheng WC; Division of Pulmonary and Critical Care, Department of Internal Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC.; School of Medicine, College of Medicine, China Medical University, No. 91, Xueshi Rd., North Dist., Taichung, 404328, Taiwan, ROC.; Department of Life Science, National Chung Hsing University, Taichung, No. 145 Xingda Rd., South Dist., Taichung, 40227, Taiwan, ROC., Hung CC; Department of Pharmacy, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC.; Department of Pharmacy, China Medical University, No. 100, Sec. 1, Jingmao Rd., Beitun Dist., Taichung, 406040, Taiwan, ROC.; Department of Healthcare Administration, Asia University, No. 500, Lioufeng Rd., Wufeng, Taichung, 41354, Taiwan, ROC., Tu CY; Division of Pulmonary and Critical Care, Department of Internal Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC.; School of Medicine, College of Medicine, China Medical University, No. 91, Xueshi Rd., North Dist., Taichung, 404328, Taiwan, ROC., Hsia TC; Division of Pulmonary and Critical Care, Department of Internal Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC.; School of Medicine, College of Medicine, China Medical University, No. 91, Xueshi Rd., North Dist., Taichung, 404328, Taiwan, ROC., Cho DY; School of Medicine, College of Medicine, China Medical University, No. 91, Xueshi Rd., North Dist., Taichung, 404328, Taiwan, ROC.; Department of Neurosurgery, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC., Hsueh PR; Department of Laboratory Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC.; Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC., Lai ZL; Department of Laboratory Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC., Shen YC; Division of Pulmonary and Critical Care, Department of Internal Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC. greywolf0127@gmail.com.; School of Medicine, College of Medicine, China Medical University, No. 91, Xueshi Rd., North Dist., Taichung, 404328, Taiwan, ROC. greywolf0127@gmail.com.; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, No. 91, Xueshi Rd., North Dist., Taichung, 404328, Taiwan, ROC. greywolf0127@gmail.com., Lin YC; Division of Pulmonary and Critical Care, Department of Internal Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC. 010001@tool.caaumed.org.tw.; School of Medicine, College of Medicine, China Medical University, No. 91, Xueshi Rd., North Dist., Taichung, 404328, Taiwan, ROC. 010001@tool.caaumed.org.tw.
Source: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2026 Jun 21. Date of Electronic Publication: 2026 Jun 21.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Smoking-associated modulation of gut microbiota shapes response to immune checkpoint inhibitors in non-small cell lung cancer.
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  Data: <searchLink fieldCode="AU" term="%22Chien+PY%22">Chien PY</searchLink>; Department of Pharmacy, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC.; Department of Pharmacy, China Medical University, No. 100, Sec. 1, Jingmao Rd., Beitun Dist., Taichung, 406040, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Cheng+WC%22">Cheng WC</searchLink>; Division of Pulmonary and Critical Care, Department of Internal Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC.; School of Medicine, College of Medicine, China Medical University, No. 91, Xueshi Rd., North Dist., Taichung, 404328, Taiwan, ROC.; Department of Life Science, National Chung Hsing University, Taichung, No. 145 Xingda Rd., South Dist., Taichung, 40227, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Hung+CC%22">Hung CC</searchLink>; Department of Pharmacy, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC.; Department of Pharmacy, China Medical University, No. 100, Sec. 1, Jingmao Rd., Beitun Dist., Taichung, 406040, Taiwan, ROC.; Department of Healthcare Administration, Asia University, No. 500, Lioufeng Rd., Wufeng, Taichung, 41354, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Tu+CY%22">Tu CY</searchLink>; Division of Pulmonary and Critical Care, Department of Internal Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC.; School of Medicine, College of Medicine, China Medical University, No. 91, Xueshi Rd., North Dist., Taichung, 404328, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Hsia+TC%22">Hsia TC</searchLink>; Division of Pulmonary and Critical Care, Department of Internal Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC.; School of Medicine, College of Medicine, China Medical University, No. 91, Xueshi Rd., North Dist., Taichung, 404328, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Cho+DY%22">Cho DY</searchLink>; School of Medicine, College of Medicine, China Medical University, No. 91, Xueshi Rd., North Dist., Taichung, 404328, Taiwan, ROC.; Department of Neurosurgery, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Hsueh+PR%22">Hsueh PR</searchLink>; Department of Laboratory Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC.; Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Lai+ZL%22">Lai ZL</searchLink>; Department of Laboratory Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Shen+YC%22">Shen YC</searchLink>; Division of Pulmonary and Critical Care, Department of Internal Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC. greywolf0127@gmail.com.; School of Medicine, College of Medicine, China Medical University, No. 91, Xueshi Rd., North Dist., Taichung, 404328, Taiwan, ROC. greywolf0127@gmail.com.; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, No. 91, Xueshi Rd., North Dist., Taichung, 404328, Taiwan, ROC. greywolf0127@gmail.com.<br /><searchLink fieldCode="AU" term="%22Lin+YC%22">Lin YC</searchLink>; Division of Pulmonary and Critical Care, Department of Internal Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan, ROC. 010001@tool.caaumed.org.tw.; School of Medicine, College of Medicine, China Medical University, No. 91, Xueshi Rd., North Dist., Taichung, 404328, Taiwan, ROC. 010001@tool.caaumed.org.tw.
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        Value: 10.1007/s00262-026-04463-3
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        Text: English
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      – TitleFull: Smoking-associated modulation of gut microbiota shapes response to immune checkpoint inhibitors in non-small cell lung cancer.
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            – D: 21
              M: 06
              Text: 2026 Jun 21
              Type: published
              Y: 2026
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