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Metformin attenuates diabetic osteoporosis via the miR-21 mediated Mef2c/Sost pathway.

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Title: Metformin attenuates diabetic osteoporosis via the miR-21 mediated Mef2c/Sost pathway.
Authors: Liu L; Department of Geriatrics, Second Hospital of Tianjin Medical University, Tianjin, China., Xu J; NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of Endocrinology, Tianjin, China., Zheng H; Endocrinology Department, TEDA International Cardiovascular Hospital, Tianjin, China., Li XC; NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of Endocrinology, Tianjin, China., Gao ZA; NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of Endocrinology, Tianjin, China., Meng C; Department of Nephrology, Kidney Disease Medical Center, General Hospital, Tianjin Medical University, National Key Clinical Specialty, Tianjin Key Medical Discipline, Tianjin, China., Pan C; NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of Endocrinology, Tianjin, China., Yang JH; Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases, Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China., Chang BC; NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of Endocrinology, Tianjin, China.
Source: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2026 Jun 05; Vol. 17, pp. 1841140. Date of Electronic Publication: 2026 Jun 05 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Metformin attenuates diabetic osteoporosis via the miR-21 mediated Mef2c/Sost pathway.
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  Data: <searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Department of Geriatrics, Second Hospital of Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of Endocrinology, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Zheng+H%22">Zheng H</searchLink>; Endocrinology Department, TEDA International Cardiovascular Hospital, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Li+XC%22">Li XC</searchLink>; NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of Endocrinology, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Gao+ZA%22">Gao ZA</searchLink>; NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of Endocrinology, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Meng+C%22">Meng C</searchLink>; Department of Nephrology, Kidney Disease Medical Center, General Hospital, Tianjin Medical University, National Key Clinical Specialty, Tianjin Key Medical Discipline, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Pan+C%22">Pan C</searchLink>; NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of Endocrinology, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Yang+JH%22">Yang JH</searchLink>; Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases, Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Chang+BC%22">Chang BC</searchLink>; NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of Endocrinology, Tianjin, China.
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  Data: <searchLink fieldCode="JN" term="%22101555782%22">Frontiers in endocrinology</searchLink> [Front Endocrinol (Lausanne)] 2026 Jun 05; Vol. 17, pp. 1841140. <i>Date of Electronic Publication: </i>2026 Jun 05 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101555782 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1664-2392 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216642392%22">16642392 </searchLink><i>NLM ISO Abbreviation: </i>Front Endocrinol (Lausanne) <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42325620
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        Value: 10.3389/fendo.2026.1841140
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              Text: 2026 Jun 05
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              Y: 2026
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