Targeting SRSF6 to Enhance Cisplatin Sensitivity by Modulating Redox Balance via NFE2L1 exon 4 Splicing in ESCC.

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Title: Targeting SRSF6 to Enhance Cisplatin Sensitivity by Modulating Redox Balance via NFE2L1 exon 4 Splicing in ESCC.
Authors: He X; State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, Henan, China.; China-US (Henan) Hormel Cancer Institute, Zhengzhou 450000, Henan, China., Xu J; State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, Henan, China.; China-US (Henan) Hormel Cancer Institute, Zhengzhou 450000, Henan, China., Duan L; State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, Henan, China.; China-US (Henan) Hormel Cancer Institute, Zhengzhou 450000, Henan, China., Ma J; China-US (Henan) Hormel Cancer Institute, Zhengzhou 450000, Henan, China., Gao D; China-US (Henan) Hormel Cancer Institute, Zhengzhou 450000, Henan, China., Xie Y; State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, Henan, China., Zhao D; State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, Henan, China.; China-US (Henan) Hormel Cancer Institute, Zhengzhou 450000, Henan, China., Liu J; State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, Henan, China.; China-US (Henan) Hormel Cancer Institute, Zhengzhou 450000, Henan, China., Zhao J; State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, Henan, China., Liu F; State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, Henan, China., Lee MH; College of Korean Medicine, Dongshin University, Naju, Republic of Korea., Kim MO; Department of Animal Science and Biotechnology, Kyungpook National University, Sangju, Republic of Korea., Dong Z; State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, Henan, China.; China-US (Henan) Hormel Cancer Institute, Zhengzhou 450000, Henan, China.; Tianjian Laboratory of Advanced Biomedical Sciences, Zhengzhou 450000, Henan, China., Jiang Y; State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, Henan, China.; China-US (Henan) Hormel Cancer Institute, Zhengzhou 450000, Henan, China.; Tianjian Laboratory of Advanced Biomedical Sciences, Zhengzhou 450000, Henan, China.; Henan International Joint Laboratory of Cancer Chemoprevention, Zhengzhou University, Zhengzhou 450000, Henan, China., Liu K; State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, Henan, China.; China-US (Henan) Hormel Cancer Institute, Zhengzhou 450000, Henan, China.; Tianjian Laboratory of Advanced Biomedical Sciences, Zhengzhou 450000, Henan, China.; Henan International Joint Laboratory of Cancer Chemoprevention, Zhengzhou University, Zhengzhou 450000, Henan, China.; Cancer Chemoprevention International Collaboration Laboratory, Zhengzhou 450000, Henan, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450000, Henan, China.
Source: International journal of biological sciences [Int J Biol Sci] 2026 Jun 10; Vol. 22 (11), pp. 6237-6260. Date of Electronic Publication: 2026 Jun 10 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1449-2288
DOI:10.7150/ijbs.131590