EML4-ALK mediates resistance to KRAS G12C inhibition and induces an oncogenic dependency by rewiring signaling through the wild-type RAS pathway.

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Title: EML4-ALK mediates resistance to KRAS G12C inhibition and induces an oncogenic dependency by rewiring signaling through the wild-type RAS pathway.
Authors: Scaparone P; University of Turin Turin, TO Italy., Mira A; University of Turin Turin, TO Italy., Cheong TC; Boston Children's Hospital Boston, MA United States., Patrucco E; University of Turin Torino Italy., Ricciuti B; Dana-Farber/Harvard Cancer Center Boston, Massachusetts United States., Gribaudo R; University of Turin Turin, TO Italy., Garbo E; Dana-Farber Cancer Institute Boston, Massachusetts United States., Scardaci R; University of Turin Turin, TO Italy., Savinelli I; University of Turin Turin, TO Italy., Vietti Michelina S; University of Turin Torino Italy., Odintsov I; University of California, San Francisco San Francisco, CA United States., Brea EJ; Dana-Farber Cancer Institute Boston, MA United States., Mignacco R; University of Turin Turin, TO Italy., Blasco RB; Boston Children's Hospital Boston United States., Santamaría D; Consejo Superior de Investigaciones Científicas (CSIC) Salamanca Spain., Voena C; University of Turin Torino Italy., Hofmann MH; Boehringer Ingelheim RCV GmbH & Co KG Vienna Austria., Nadal E; Institut Català d'Oncologia L'Hospitalet de Llobregat, Barcelona Spain., Novello S; University of Turin Orbassano, TO Italy., Awad MM; Memorial Sloan Kettering Cancer Center Boston, Massachusetts United States., Chiarle R; Boston Children's Hospital Boston United States., Ambrogio C; University of Turin Turin, TO Italy.
Source: Cancer discovery [Cancer Discov] 2026 Jun 22. Date of Electronic Publication: 2026 Jun 22.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2159-8290
DOI:10.1158/2159-8290.CD-25-0477