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Interim Estimated Effectiveness of 2025-2026 COVID-19 Vaccines in Adults Using a Test-Negative Design.

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Title: Interim Estimated Effectiveness of 2025-2026 COVID-19 Vaccines in Adults Using a Test-Negative Design.
Authors: Wiegand RE; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia., Chickery S; Westat, Bethesda, Maryland., Yang DH; Westat, Bethesda, Maryland., Ball SW; Westat, Bethesda, Maryland., DeSilva MB; HealthPartners Institute, Minneapolis, Minnesota., Dascomb K; Division of Infectious Diseases and Clinical Epidemiology, Intermountain Health, Salt Lake City, Utah., Irving SA; Kaiser Permanente Center for Health Research, Portland, Oregon., Natarajan K; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, New York., Klein NP; Kaiser Permanente Vaccine Study Center, Kaiser Permanente Northern California Division of Research, Oakland., Grannis SJ; Center for Biomedical Informatics, Regenstrief Institute, Indianapolis, Indiana.; Department of Family Medicine, School of Medicine, Indiana University, Indianapolis., Ong TC; School of Medicine, University of Colorado Anschutz Medical Campus, Aurora., Rowley EAK; Westat, Bethesda, Maryland., Yates A; Westat, Bethesda, Maryland., Zhuang Y; Westat, Bethesda, Maryland., Wilson S; Westat, Bethesda, Maryland., McEvoy CE; HealthPartners Institute, Minneapolis, Minnesota., Essien IJ; HealthPartners Institute, Minneapolis, Minnesota., Akinsete OO; HealthPartners Institute, Minneapolis, Minnesota., Naleway AL; Kaiser Permanente Center for Health Research, Portland, Oregon., Koppolu P; Kaiser Permanente Center for Health Research, Portland, Oregon., Zerbo O; Kaiser Permanente Vaccine Study Center, Kaiser Permanente Northern California Division of Research, Oakland., Hansen JR; Kaiser Permanente Vaccine Study Center, Kaiser Permanente Northern California Division of Research, Oakland., Jacobson KB; Kaiser Permanente Vaccine Study Center, Kaiser Permanente Northern California Division of Research, Oakland., Block L; Kaiser Permanente Vaccine Study Center, Kaiser Permanente Northern California Division of Research, Oakland., Dixon BE; Center for Biomedical Informatics, Regenstrief Institute, Indianapolis, Indiana.; Department of Health Policy and Management, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis., Duszynski T; Center for Biomedical Informatics, Regenstrief Institute, Indianapolis, Indiana.; Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis., Rogerson C; Center for Biomedical Informatics, Regenstrief Institute, Indianapolis, Indiana.; Department of Pediatrics, School of Medicine, Indiana University, Indianapolis., Barron MA; School of Medicine, University of Colorado Anschutz Medical Campus, Aurora., Chavez C; School of Medicine, University of Colorado Anschutz Medical Campus, Aurora., Mak J; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia., Ciesla AA; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.; Eagle Health Analytics, San Antonio, Texas., Godfrey M; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia., Kautz A; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.; General Dynamics Information Technology, Atlanta, Georgia., Najdowski M; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.; Eagle Health Analytics, San Antonio, Texas., Link-Gelles R; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.; US Public Health Service Commissioned Corps, Rockville, Maryland., DeCuir J; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia., Payne AB; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Source: JAMA network open [JAMA Netw Open] 2026 Jun 01; Vol. 9 (6), pp. e2625152. Date of Electronic Publication: 2026 Jun 01.
Publication Type: Journal Article
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE
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  Data: Interim Estimated Effectiveness of 2025-2026 COVID-19 Vaccines in Adults Using a Test-Negative Design.
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  Data: <searchLink fieldCode="AU" term="%22Wiegand+RE%22">Wiegand RE</searchLink>; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Chickery+S%22">Chickery S</searchLink>; Westat, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Yang+DH%22">Yang DH</searchLink>; Westat, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Ball+SW%22">Ball SW</searchLink>; Westat, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22DeSilva+MB%22">DeSilva MB</searchLink>; HealthPartners Institute, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Dascomb+K%22">Dascomb K</searchLink>; Division of Infectious Diseases and Clinical Epidemiology, Intermountain Health, Salt Lake City, Utah.<br /><searchLink fieldCode="AU" term="%22Irving+SA%22">Irving SA</searchLink>; Kaiser Permanente Center for Health Research, Portland, Oregon.<br /><searchLink fieldCode="AU" term="%22Natarajan+K%22">Natarajan K</searchLink>; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Klein+NP%22">Klein NP</searchLink>; Kaiser Permanente Vaccine Study Center, Kaiser Permanente Northern California Division of Research, Oakland.<br /><searchLink fieldCode="AU" term="%22Grannis+SJ%22">Grannis SJ</searchLink>; Center for Biomedical Informatics, Regenstrief Institute, Indianapolis, Indiana.; Department of Family Medicine, School of Medicine, Indiana University, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Ong+TC%22">Ong TC</searchLink>; School of Medicine, University of Colorado Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Rowley+EAK%22">Rowley EAK</searchLink>; Westat, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Yates+A%22">Yates A</searchLink>; Westat, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Zhuang+Y%22">Zhuang Y</searchLink>; Westat, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22Wilson+S%22">Wilson S</searchLink>; Westat, Bethesda, Maryland.<br /><searchLink fieldCode="AU" term="%22McEvoy+CE%22">McEvoy CE</searchLink>; HealthPartners Institute, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Essien+IJ%22">Essien IJ</searchLink>; HealthPartners Institute, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Akinsete+OO%22">Akinsete OO</searchLink>; HealthPartners Institute, Minneapolis, Minnesota.<br /><searchLink fieldCode="AU" term="%22Naleway+AL%22">Naleway AL</searchLink>; Kaiser Permanente Center for Health Research, Portland, Oregon.<br /><searchLink fieldCode="AU" term="%22Koppolu+P%22">Koppolu P</searchLink>; Kaiser Permanente Center for Health Research, Portland, Oregon.<br /><searchLink fieldCode="AU" term="%22Zerbo+O%22">Zerbo O</searchLink>; Kaiser Permanente Vaccine Study Center, Kaiser Permanente Northern California Division of Research, Oakland.<br /><searchLink fieldCode="AU" term="%22Hansen+JR%22">Hansen JR</searchLink>; Kaiser Permanente Vaccine Study Center, Kaiser Permanente Northern California Division of Research, Oakland.<br /><searchLink fieldCode="AU" term="%22Jacobson+KB%22">Jacobson KB</searchLink>; Kaiser Permanente Vaccine Study Center, Kaiser Permanente Northern California Division of Research, Oakland.<br /><searchLink fieldCode="AU" term="%22Block+L%22">Block L</searchLink>; Kaiser Permanente Vaccine Study Center, Kaiser Permanente Northern California Division of Research, Oakland.<br /><searchLink fieldCode="AU" term="%22Dixon+BE%22">Dixon BE</searchLink>; Center for Biomedical Informatics, Regenstrief Institute, Indianapolis, Indiana.; Department of Health Policy and Management, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Duszynski+T%22">Duszynski T</searchLink>; Center for Biomedical Informatics, Regenstrief Institute, Indianapolis, Indiana.; Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Rogerson+C%22">Rogerson C</searchLink>; Center for Biomedical Informatics, Regenstrief Institute, Indianapolis, Indiana.; Department of Pediatrics, School of Medicine, Indiana University, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Barron+MA%22">Barron MA</searchLink>; School of Medicine, University of Colorado Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Chavez+C%22">Chavez C</searchLink>; School of Medicine, University of Colorado Anschutz Medical Campus, Aurora.<br /><searchLink fieldCode="AU" term="%22Mak+J%22">Mak J</searchLink>; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Ciesla+AA%22">Ciesla AA</searchLink>; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.; Eagle Health Analytics, San Antonio, Texas.<br /><searchLink fieldCode="AU" term="%22Godfrey+M%22">Godfrey M</searchLink>; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Kautz+A%22">Kautz A</searchLink>; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.; General Dynamics Information Technology, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Najdowski+M%22">Najdowski M</searchLink>; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.; Eagle Health Analytics, San Antonio, Texas.<br /><searchLink fieldCode="AU" term="%22Link-Gelles+R%22">Link-Gelles R</searchLink>; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.; US Public Health Service Commissioned Corps, Rockville, Maryland.<br /><searchLink fieldCode="AU" term="%22DeCuir+J%22">DeCuir J</searchLink>; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Payne+AB%22">Payne AB</searchLink>; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
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