An emergent disease-associated motor neuron state precedes cell death in ALS.

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Title: An emergent disease-associated motor neuron state precedes cell death in ALS.
Authors: Gautier O; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Neurosciences Graduate Program, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: ogautier@stanford.edu., Blum JA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Nguyen TP; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Cao S; Research, Biogen Inc., Cambridge, MA 02142, USA., Klemm S; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Yamakawa M; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Huh D; Research, Biogen Inc., Cambridge, MA 02142, USA., Hurt JA; Research, Biogen Inc., Cambridge, MA 02142, USA., Sinnott-Armstrong N; Herbold Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98195, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Brotman Baty Institute, University of Washington, Seattle, WA 98195, USA., Zeng Y; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Biohub - San Francisco, San Francisco, CA 94158, USA., Davis CO; Department of Neurobiology, Stanford University, Stanford, CA 94305, USA., Bombosch J; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Liu C; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Encarnacion LN; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Guttenplan KA; Vollum Institute, Oregon Health and Sciences University, Portland, OR 97239, USA., Chen D; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Kathiria A; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Zhao L; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Moore S; Departments of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Meng A; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA., Ong K; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA., Cleveland DW; Departments of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Ravits J; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA., Rexach JE; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Greenleaf WJ; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA; Biohub - San Francisco, San Francisco, CA 94158, USA., Gitler AD; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Biohub - San Francisco, San Francisco, CA 94158, USA; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA 94305, USA. Electronic address: agitler@stanford.edu.
Source: Cell [Cell] 2026 Jun 23. Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4172
DOI:10.1016/j.cell.2026.05.047