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An emergent disease-associated motor neuron state precedes cell death in ALS.

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Title: An emergent disease-associated motor neuron state precedes cell death in ALS.
Authors: Gautier O; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Neurosciences Graduate Program, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: ogautier@stanford.edu., Blum JA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Nguyen TP; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Cao S; Research, Biogen Inc., Cambridge, MA 02142, USA., Klemm S; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Yamakawa M; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Huh D; Research, Biogen Inc., Cambridge, MA 02142, USA., Hurt JA; Research, Biogen Inc., Cambridge, MA 02142, USA., Sinnott-Armstrong N; Herbold Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98195, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Brotman Baty Institute, University of Washington, Seattle, WA 98195, USA., Zeng Y; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Biohub - San Francisco, San Francisco, CA 94158, USA., Davis CO; Department of Neurobiology, Stanford University, Stanford, CA 94305, USA., Bombosch J; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Liu C; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Encarnacion LN; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Guttenplan KA; Vollum Institute, Oregon Health and Sciences University, Portland, OR 97239, USA., Chen D; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Kathiria A; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Zhao L; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Moore S; Departments of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Meng A; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA., Ong K; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA., Cleveland DW; Departments of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Ravits J; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA., Rexach JE; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Greenleaf WJ; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA; Biohub - San Francisco, San Francisco, CA 94158, USA., Gitler AD; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Biohub - San Francisco, San Francisco, CA 94158, USA; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA 94305, USA. Electronic address: agitler@stanford.edu.
Source: Cell [Cell] 2026 Jun 23. Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
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  Data: An emergent disease-associated motor neuron state precedes cell death in ALS.
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  Data: <searchLink fieldCode="AU" term="%22Gautier+O%22">Gautier O</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Neurosciences Graduate Program, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: ogautier@stanford.edu.<br /><searchLink fieldCode="AU" term="%22Blum+JA%22">Blum JA</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+TP%22">Nguyen TP</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Cao+S%22">Cao S</searchLink>; Research, Biogen Inc., Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Klemm+S%22">Klemm S</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Yamakawa+M%22">Yamakawa M</searchLink>; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.<br /><searchLink fieldCode="AU" term="%22Huh+D%22">Huh D</searchLink>; Research, Biogen Inc., Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Hurt+JA%22">Hurt JA</searchLink>; Research, Biogen Inc., Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Sinnott-Armstrong+N%22">Sinnott-Armstrong N</searchLink>; Herbold Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98195, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Brotman Baty Institute, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Zeng+Y%22">Zeng Y</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Biohub - San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Davis+CO%22">Davis CO</searchLink>; Department of Neurobiology, Stanford University, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Bombosch+J%22">Bombosch J</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Encarnacion+LN%22">Encarnacion LN</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Guttenplan+KA%22">Guttenplan KA</searchLink>; Vollum Institute, Oregon Health and Sciences University, Portland, OR 97239, USA.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Kathiria+A%22">Kathiria A</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+L%22">Zhao L</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Moore+S%22">Moore S</searchLink>; Departments of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Meng+A%22">Meng A</searchLink>; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Ong+K%22">Ong K</searchLink>; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Cleveland+DW%22">Cleveland DW</searchLink>; Departments of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Ravits+J%22">Ravits J</searchLink>; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Rexach+JE%22">Rexach JE</searchLink>; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.<br /><searchLink fieldCode="AU" term="%22Greenleaf+WJ%22">Greenleaf WJ</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA; Biohub - San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Gitler+AD%22">Gitler AD</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Biohub - San Francisco, San Francisco, CA 94158, USA; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA 94305, USA. Electronic address: agitler@stanford.edu.
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  Data: <searchLink fieldCode="JN" term="%220413066%22">Cell</searchLink> [Cell] 2026 Jun 23. <i>Date of Electronic Publication: </i>2026 Jun 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0413066 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-4172 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200928674%22">00928674 </searchLink><i>NLM ISO Abbreviation: </i>Cell <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.cell.2026.05.047
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