Autoantigen-loaded Polymeric Microparticles associate with B cells and promote tolerogenic antigen presentation in a mouse model of experimental autoimmune encephalomyelitis.

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Title: Autoantigen-loaded Polymeric Microparticles associate with B cells and promote tolerogenic antigen presentation in a mouse model of experimental autoimmune encephalomyelitis.
Authors: Lukesh NR; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA., Barbery BG; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA., Clark KA; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA., Ontiveros-Padilla L; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA., Ehrenzeller SA; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA., Woodring RN; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA., Mendell SE; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA., Middleton DD; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA., Islam MJ; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA., Pena ES; Department of Biomedical Engineering, NC State/UNC, Chapel Hill, NC, USA., Hendy DA; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA., Simpson SR; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA., Graham-Gurysh EG; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA., Lopez AM; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA., Murphy CT; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA., Williamson GL; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA., Ly SA; Department of Biomedical Engineering, NC State/UNC, Chapel Hill, NC, USA., Shilling KE; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA., Landoni E; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA., Stiepel RT; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA., Sherwin D; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Genetics, School of Medicine, UNC, Chapel Hill, NC, USA., Ke Q; Department of Microbiology and Immunology, School of Medicine, UNC, Chapel Hill, NC, USA., Savoldo B; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA., Dotti G; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Microbiology and Immunology, School of Medicine, UNC, Chapel Hill, NC, USA., Pylayeva-Gupta Y; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Genetics, School of Medicine, UNC, Chapel Hill, NC, USA., Tisch RM; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Microbiology and Immunology, School of Medicine, UNC, Chapel Hill, NC, USA., Bachelder EM; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA., Ainslie KM; Division of Pharmacoengineering & Molecular Pharmaceutics, Eshelman School of Pharmacy, UNC, Chapel Hill, NC, USA. ainsliek@email.unc.edu.; Department of Biomedical Engineering, NC State/UNC, Chapel Hill, NC, USA. ainsliek@email.unc.edu.; Department of Microbiology and Immunology, School of Medicine, UNC, Chapel Hill, NC, USA. ainsliek@email.unc.edu.
Source: Nature communications [Nat Commun] 2026 Jun 23. Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-74641-5