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Cortical gray-white matter contrast alterations precede amyloid-β positivity and macrostructural changes in older adults without dementia.

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Title: Cortical gray-white matter contrast alterations precede amyloid-β positivity and macrostructural changes in older adults without dementia.
Authors: Pieperhoff L; Department of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands.; Brain imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands., Lorenzini L; Department of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands.; Brain imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands.; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy., Almeida F; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; Department of Neuroradiology, Hospital de Braga, ULS Braga, Braga, Portugal., Tranfa M; Department of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands.; Brain imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands.; Department of Anatomy and Neurosciences, Amsterdam UMC location VUmc, Amsterdam, the Netherlands.; Neurodegeneration, Amsterdam Neuroscience, Amsterdam, the Netherlands.; Department of Advanced Biomedical Sciences, University of Naples 'Federico II', Naples, Italy., Bollack A; GE HealthCare, Amersham, UK.; Department of Medical Physics and Biomedical Engineering, UCL, London, UK., Arunachalam P; Department of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands.; Brain imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands., Masserini F; Department of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands.; Brain imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands.; 'L. Sacco' Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy., Wolz R; IXICO plc London, London, UK., Grootoonk S; IXICO plc London, London, UK., Ritchie C; Scottish Brain Sciences, Edinburgh, UK., Boada M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Marquié M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Vijverberg J; Brain imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands.; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC, Amsterdam, the Netherlands., Vandenberghe R; Laboratory for Cognitive Neurology, KU Leuven, Leuven, Belgium., Hanseeuw BJ; Department of Neurology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.; Institute of Neuroscience, Université catholique de Louvain, Brussels, Belgium., Martinez-Lage P; Center for Research and Advanced Therapies. CITA Alzheimer Foundation, Donostia-San Sebastián, Spain., Payoux P; ToNIC Toulouse NeuroImaging Center, Université Toulouse 3, Inserm, Toulouse, France., Visser PJ; Brain imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands.; Alzheimer Center Amsterdam, Neurology, Amsterdam UMC, Amsterdam, the Netherlands., Schöll M; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.; Dementia Research Centre, Institute of Neurology, University College London, London, UK., Frisoni GB; Hôpitaux Universitaires de Genève, Geneva, Switzerland., Pardini M; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.; IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Roccataglia L; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.; Department of Neuroradiology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Stephens AW; Life Molecular Imaging GmbH, Berlin, Germany., Buckley C; GE HealthCare, Amersham, UK., Farrar G; GE HealthCare, Amersham, UK., Jessen F; Department of Psychiatry and Psychotherapy, University Hospital Cologne, Cologne, Germany., Gispert JD; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain., Salvadó G; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.; Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden., Luckett ES; Department of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands.; Brain imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands.; Laboratory for Cognitive Neurology, KU Leuven, Leuven, Belgium.; Laboratory for Complex Genetics, KU Leuven, Leuven, Belgium., Mutsaerts HM; Department of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands.; Brain imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands., Wink AM; Department of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands.; Brain imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands., Collij LE; Department of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands.; Brain imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands., Barkhof F; Department of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands.; Brain imaging, Amsterdam Neuroscience, Amsterdam, the Netherlands., Oliveira TG; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; Department of Neuroradiology, Hospital de Braga, ULS Braga, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, University of Minho, Braga, Portugal.
Corporate Authors: AMYPAD consortium
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Jun; Vol. 22 (6), pp. e71609.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cortical gray-white matter contrast alterations precede amyloid-β positivity and macrostructural changes in older adults without dementia.
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              Text: 2026 Jun
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