HDAC inhibition sensitizes pancreatic tumors to DNA damage by global redistribution of the transcriptional machinery.

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Title: HDAC inhibition sensitizes pancreatic tumors to DNA damage by global redistribution of the transcriptional machinery.
Authors: Liang G; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Nguyen HV; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755., Zhu J; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Tiriac H; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093., Zafar H; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139., Cao DY; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Estepa G; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Nelson DC; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Dai Y; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Oh TG; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Liddle C; Storr Liver Centre, Westmead Institute for Medical Research and Sydney Medical School, University of Sydney, Westmead, NSW 2145, Australia., Yu RT; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Hunter T; Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Engle D; Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Shaw R; Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Lowy AM; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093., Fan W; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Truitt ML; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Atkins AR; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Johnson JA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139., Downes M; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Evans RM; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jun 30; Vol. 123 (26), pp. e2536040123. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2536040123