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HDAC inhibition sensitizes pancreatic tumors to DNA damage by global redistribution of the transcriptional machinery.

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Title: HDAC inhibition sensitizes pancreatic tumors to DNA damage by global redistribution of the transcriptional machinery.
Authors: Liang G; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Nguyen HV; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755., Zhu J; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Tiriac H; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093., Zafar H; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139., Cao DY; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Estepa G; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Nelson DC; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Dai Y; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Oh TG; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Liddle C; Storr Liver Centre, Westmead Institute for Medical Research and Sydney Medical School, University of Sydney, Westmead, NSW 2145, Australia., Yu RT; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Hunter T; Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Engle D; Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Shaw R; Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Lowy AM; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093., Fan W; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Truitt ML; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Atkins AR; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Johnson JA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139., Downes M; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037., Evans RM; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jun 30; Vol. 123 (26), pp. e2536040123. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: HDAC inhibition sensitizes pancreatic tumors to DNA damage by global redistribution of the transcriptional machinery.
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  Data: <searchLink fieldCode="AU" term="%22Liang+G%22">Liang G</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Nguyen+HV%22">Nguyen HV</searchLink>; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Tiriac+H%22">Tiriac H</searchLink>; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093.<br /><searchLink fieldCode="AU" term="%22Zafar+H%22">Zafar H</searchLink>; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.<br /><searchLink fieldCode="AU" term="%22Cao+DY%22">Cao DY</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Estepa+G%22">Estepa G</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Nelson+DC%22">Nelson DC</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Dai+Y%22">Dai Y</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Oh+TG%22">Oh TG</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Liddle+C%22">Liddle C</searchLink>; Storr Liver Centre, Westmead Institute for Medical Research and Sydney Medical School, University of Sydney, Westmead, NSW 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Yu+RT%22">Yu RT</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Hunter+T%22">Hunter T</searchLink>; Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Engle+D%22">Engle D</searchLink>; Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Shaw+R%22">Shaw R</searchLink>; Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Lowy+AM%22">Lowy AM</searchLink>; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093.<br /><searchLink fieldCode="AU" term="%22Fan+W%22">Fan W</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Truitt+ML%22">Truitt ML</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Atkins+AR%22">Atkins AR</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Johnson+JA%22">Johnson JA</searchLink>; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.<br /><searchLink fieldCode="AU" term="%22Downes+M%22">Downes M</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.<br /><searchLink fieldCode="AU" term="%22Evans+RM%22">Evans RM</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Jun 30; Vol. 123 (26), pp. e2536040123. <i>Date of Electronic Publication: </i>2026 Jun 25.
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