Efficacy of a comprehensive medication management programme on medication adherence in patients with heart failure and polypharmacy (PERSEUS-HF): study protocol for a multicentre randomised controlled trial.

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Title: Efficacy of a comprehensive medication management programme on medication adherence in patients with heart failure and polypharmacy (PERSEUS-HF): study protocol for a multicentre randomised controlled trial.
Authors: Kagami K; Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan., Kondo T; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Suzuki S; Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan., Saito Y; Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan., Fujiki S; Department of Cardiovascular and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Takahashi S; Department of Cardiology, National Hospital Organization Takasaki General Medical Center, Takasaki, Japan., Iwano H; Division of Cardiology, Teine Keijinkai Hospital, Sapporo, Japan., Omote K; Department of Cardiology, Hokkaido Cardiovascular Hospital, Sapporo, Japan., Jujo K; Department of Cardiology, Saitama Medical Center, Kawagoe, Japan., Nagatomo Y; Department of Cardiology, National Defense Medical College, Tokorozawa, Japan., Abe H; Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan., Kinugasa Y; Department of Cardiovascular Medicine and Endocrinology and Metabolism, Faculty of Medicine, Tottori University, Yonago, Japan., Tanabe J; Division of Cardiology, Shimane University Faculty of Medicine, Izumo, Japan., Sakamoto T; Division of Cardiology, Shimane University Faculty of Medicine, Izumo, Japan.; Department of Internal Medicine, Izumo City General Hospital, Izumo, Japan., Araki T; Department of Pharmacy, Gunma University Graduate School of Medicine, Maebashi, Japan., Minamisawa M; Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan., Ishii H; Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan., Obokata M; Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan obokata.masaru@gunma-u.ac.jp.
Source: BMJ open [BMJ Open] 2026 Jun 25; Vol. 16 (6), pp. e116761. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2044-6055
DOI:10.1136/bmjopen-2026-116761