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Efficacy of a comprehensive medication management programme on medication adherence in patients with heart failure and polypharmacy (PERSEUS-HF): study protocol for a multicentre randomised controlled trial.

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Title: Efficacy of a comprehensive medication management programme on medication adherence in patients with heart failure and polypharmacy (PERSEUS-HF): study protocol for a multicentre randomised controlled trial.
Authors: Kagami K; Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan., Kondo T; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Suzuki S; Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan., Saito Y; Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan., Fujiki S; Department of Cardiovascular and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Takahashi S; Department of Cardiology, National Hospital Organization Takasaki General Medical Center, Takasaki, Japan., Iwano H; Division of Cardiology, Teine Keijinkai Hospital, Sapporo, Japan., Omote K; Department of Cardiology, Hokkaido Cardiovascular Hospital, Sapporo, Japan., Jujo K; Department of Cardiology, Saitama Medical Center, Kawagoe, Japan., Nagatomo Y; Department of Cardiology, National Defense Medical College, Tokorozawa, Japan., Abe H; Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan., Kinugasa Y; Department of Cardiovascular Medicine and Endocrinology and Metabolism, Faculty of Medicine, Tottori University, Yonago, Japan., Tanabe J; Division of Cardiology, Shimane University Faculty of Medicine, Izumo, Japan., Sakamoto T; Division of Cardiology, Shimane University Faculty of Medicine, Izumo, Japan.; Department of Internal Medicine, Izumo City General Hospital, Izumo, Japan., Araki T; Department of Pharmacy, Gunma University Graduate School of Medicine, Maebashi, Japan., Minamisawa M; Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan., Ishii H; Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan., Obokata M; Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan obokata.masaru@gunma-u.ac.jp.
Source: BMJ open [BMJ Open] 2026 Jun 25; Vol. 16 (6), pp. e116761. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
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  Data: Efficacy of a comprehensive medication management programme on medication adherence in patients with heart failure and polypharmacy (PERSEUS-HF): study protocol for a multicentre randomised controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Kagami+K%22">Kagami K</searchLink>; Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.<br /><searchLink fieldCode="AU" term="%22Kondo+T%22">Kondo T</searchLink>; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+S%22">Suzuki S</searchLink>; Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan.<br /><searchLink fieldCode="AU" term="%22Saito+Y%22">Saito Y</searchLink>; Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Fujiki+S%22">Fujiki S</searchLink>; Department of Cardiovascular and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+S%22">Takahashi S</searchLink>; Department of Cardiology, National Hospital Organization Takasaki General Medical Center, Takasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Iwano+H%22">Iwano H</searchLink>; Division of Cardiology, Teine Keijinkai Hospital, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Omote+K%22">Omote K</searchLink>; Department of Cardiology, Hokkaido Cardiovascular Hospital, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Jujo+K%22">Jujo K</searchLink>; Department of Cardiology, Saitama Medical Center, Kawagoe, Japan.<br /><searchLink fieldCode="AU" term="%22Nagatomo+Y%22">Nagatomo Y</searchLink>; Department of Cardiology, National Defense Medical College, Tokorozawa, Japan.<br /><searchLink fieldCode="AU" term="%22Abe+H%22">Abe H</searchLink>; Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kinugasa+Y%22">Kinugasa Y</searchLink>; Department of Cardiovascular Medicine and Endocrinology and Metabolism, Faculty of Medicine, Tottori University, Yonago, Japan.<br /><searchLink fieldCode="AU" term="%22Tanabe+J%22">Tanabe J</searchLink>; Division of Cardiology, Shimane University Faculty of Medicine, Izumo, Japan.<br /><searchLink fieldCode="AU" term="%22Sakamoto+T%22">Sakamoto T</searchLink>; Division of Cardiology, Shimane University Faculty of Medicine, Izumo, Japan.; Department of Internal Medicine, Izumo City General Hospital, Izumo, Japan.<br /><searchLink fieldCode="AU" term="%22Araki+T%22">Araki T</searchLink>; Department of Pharmacy, Gunma University Graduate School of Medicine, Maebashi, Japan.<br /><searchLink fieldCode="AU" term="%22Minamisawa+M%22">Minamisawa M</searchLink>; Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan.<br /><searchLink fieldCode="AU" term="%22Ishii+H%22">Ishii H</searchLink>; Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.<br /><searchLink fieldCode="AU" term="%22Obokata+M%22">Obokata M</searchLink>; Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan obokata.masaru@gunma-u.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%22101552874%22">BMJ open</searchLink> [BMJ Open] 2026 Jun 25; Vol. 16 (6), pp. e116761. <i>Date of Electronic Publication: </i>2026 Jun 25.
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