Widespread synaptic density loss in schizophrenia follows molecular and network architecture.

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Title: Widespread synaptic density loss in schizophrenia follows molecular and network architecture.
Authors: Chopra S; Department of Psychology, Yale University, New Haven, CT, USA. sidhantchopra4@gmail.com.; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Melbourne, VIC, Australia. sidhantchopra4@gmail.com.; Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia. sidhantchopra4@gmail.com., Worhunsky PD; Department of Psychiatry, Yale University, New Haven, CT, USA., Naganawa M; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA., Zhang XH; Department of Psychology, Yale University, New Haven, CT, USA., Segal A; Department of Neuroscience, Yale University, New Haven, CT, USA., Labache L; Department of Psychiatry, Brain Health Institute, Rutgers University, Piscataway, NJ, USA., Orchard E; Department of Psychology, Yale University, New Haven, CT, USA.; Ann S. Bowers Women's Brain Health Initiative, University of California Santa Barbara, Santa Barbara, CA, USA., Cropley V; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Melbourne, VIC, Australia.; Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia., Wood S; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Melbourne, VIC, Australia.; Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia.; School of Psychology, University of Birmingham, Birmingham, UK., Angarita GA; Department of Psychiatry, Yale University, New Haven, CT, USA., Cosgrove K; Department of Psychiatry, Yale University, New Haven, CT, USA., Matuskey D; Department of Psychiatry, Yale University, New Haven, CT, USA.; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA., Nabulsi NB; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA., Huang Y; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA., Carson RE; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA., Esterlis I; Department of Psychology, Yale University, New Haven, CT, USA.; Department of Psychiatry, Yale University, New Haven, CT, USA.; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA., Skosnik PD; Department of Psychiatry, Yale University, New Haven, CT, USA., D'Souza DC; Department of Psychiatry, Yale University, New Haven, CT, USA., Holmes AJ; Department of Psychiatry, Brain Health Institute, Rutgers University, Piscataway, NJ, USA., Radhakrishnan R; Department of Psychiatry, Yale University, New Haven, CT, USA.; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Jun 25. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-026-03717-x