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Widespread synaptic density loss in schizophrenia follows molecular and network architecture.

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Title: Widespread synaptic density loss in schizophrenia follows molecular and network architecture.
Authors: Chopra S; Department of Psychology, Yale University, New Haven, CT, USA. sidhantchopra4@gmail.com.; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Melbourne, VIC, Australia. sidhantchopra4@gmail.com.; Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia. sidhantchopra4@gmail.com., Worhunsky PD; Department of Psychiatry, Yale University, New Haven, CT, USA., Naganawa M; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA., Zhang XH; Department of Psychology, Yale University, New Haven, CT, USA., Segal A; Department of Neuroscience, Yale University, New Haven, CT, USA., Labache L; Department of Psychiatry, Brain Health Institute, Rutgers University, Piscataway, NJ, USA., Orchard E; Department of Psychology, Yale University, New Haven, CT, USA.; Ann S. Bowers Women's Brain Health Initiative, University of California Santa Barbara, Santa Barbara, CA, USA., Cropley V; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Melbourne, VIC, Australia.; Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia., Wood S; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Melbourne, VIC, Australia.; Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia.; School of Psychology, University of Birmingham, Birmingham, UK., Angarita GA; Department of Psychiatry, Yale University, New Haven, CT, USA., Cosgrove K; Department of Psychiatry, Yale University, New Haven, CT, USA., Matuskey D; Department of Psychiatry, Yale University, New Haven, CT, USA.; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA., Nabulsi NB; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA., Huang Y; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA., Carson RE; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA., Esterlis I; Department of Psychology, Yale University, New Haven, CT, USA.; Department of Psychiatry, Yale University, New Haven, CT, USA.; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA., Skosnik PD; Department of Psychiatry, Yale University, New Haven, CT, USA., D'Souza DC; Department of Psychiatry, Yale University, New Haven, CT, USA., Holmes AJ; Department of Psychiatry, Brain Health Institute, Rutgers University, Piscataway, NJ, USA., Radhakrishnan R; Department of Psychiatry, Yale University, New Haven, CT, USA.; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Jun 25. Date of Electronic Publication: 2026 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Chopra+S%22">Chopra S</searchLink>; Department of Psychology, Yale University, New Haven, CT, USA. sidhantchopra4@gmail.com.; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Melbourne, VIC, Australia. sidhantchopra4@gmail.com.; Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia. sidhantchopra4@gmail.com.<br /><searchLink fieldCode="AU" term="%22Worhunsky+PD%22">Worhunsky PD</searchLink>; Department of Psychiatry, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Naganawa+M%22">Naganawa M</searchLink>; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+XH%22">Zhang XH</searchLink>; Department of Psychology, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Segal+A%22">Segal A</searchLink>; Department of Neuroscience, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Labache+L%22">Labache L</searchLink>; Department of Psychiatry, Brain Health Institute, Rutgers University, Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Orchard+E%22">Orchard E</searchLink>; Department of Psychology, Yale University, New Haven, CT, USA.; Ann S. Bowers Women's Brain Health Initiative, University of California Santa Barbara, Santa Barbara, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cropley+V%22">Cropley V</searchLink>; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Melbourne, VIC, Australia.; Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Wood+S%22">Wood S</searchLink>; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Melbourne, VIC, Australia.; Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia.; School of Psychology, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Angarita+GA%22">Angarita GA</searchLink>; Department of Psychiatry, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Cosgrove+K%22">Cosgrove K</searchLink>; Department of Psychiatry, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Matuskey+D%22">Matuskey D</searchLink>; Department of Psychiatry, Yale University, New Haven, CT, USA.; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Nabulsi+NB%22">Nabulsi NB</searchLink>; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Carson+RE%22">Carson RE</searchLink>; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Esterlis+I%22">Esterlis I</searchLink>; Department of Psychology, Yale University, New Haven, CT, USA.; Department of Psychiatry, Yale University, New Haven, CT, USA.; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Skosnik+PD%22">Skosnik PD</searchLink>; Department of Psychiatry, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22D'Souza+DC%22">D'Souza DC</searchLink>; Department of Psychiatry, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Holmes+AJ%22">Holmes AJ</searchLink>; Department of Psychiatry, Brain Health Institute, Rutgers University, Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Radhakrishnan+R%22">Radhakrishnan R</searchLink>; Department of Psychiatry, Yale University, New Haven, CT, USA.; Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
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