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Actin derangement and increased Piezo1 activity in Ras-transformed cells promote cyclic stretch-induced cell detachment and apoptosis.

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Title: Actin derangement and increased Piezo1 activity in Ras-transformed cells promote cyclic stretch-induced cell detachment and apoptosis.
Authors: Wong TY; International Center for Wound Repair and Regeneration, National Cheng Kung University, No.1 University Road, Tainan City, 701, Taiwan.; Cross College Elite Program, National Cheng Kung University, No.1 University Road, Tainan City, 701, Taiwan., Lee LW; International Center for Wound Repair and Regeneration, National Cheng Kung University, No.1 University Road, Tainan City, 701, Taiwan.; Department of Physiology, College of Medicine, National Cheng Kung University, No.1 University Road, Tainan City, 701, Taiwan., Lee GH; International Center for Wound Repair and Regeneration, National Cheng Kung University, No.1 University Road, Tainan City, 701, Taiwan., Huang JY; International Center for Wound Repair and Regeneration, National Cheng Kung University, No.1 University Road, Tainan City, 701, Taiwan., Tang MJ; International Center for Wound Repair and Regeneration, National Cheng Kung University, No.1 University Road, Tainan City, 701, Taiwan. mjtang1@mail.ncku.edu.tw.; Department of Physiology, College of Medicine, National Cheng Kung University, No.1 University Road, Tainan City, 701, Taiwan. mjtang1@mail.ncku.edu.tw.
Source: Scientific reports [Sci Rep] 2026 Jun 26. Date of Electronic Publication: 2026 Jun 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2045-2322
DOI:10.1038/s41598-026-59854-4