Dexamethasone reduces osteogenic potential through suppressing retinoic acid signaling via NF-κB/CYP26B1 axis in mesenchymal stem cells.

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Title: Dexamethasone reduces osteogenic potential through suppressing retinoic acid signaling via NF-κB/CYP26B1 axis in mesenchymal stem cells.
Authors: Ye AH; Key Laboratory of Biochemistry and Molecular Pharmacology of Chongqing, Chongqing Medical University, Chongqing, 400016, People's Republic of China.; Department of Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, People's Republic of China., Wang YM; Department of Bone and Soft Tissue Tumors, School of Medicine, Chongqing University Cancer Hospital, Chongqing University, No. 181 Hanyu Road, Shapingba District, Chongqing, 400030, China.; Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, 400030, China., Wan XY; Department of Bone and Soft Tissue Tumors, School of Medicine, Chongqing University Cancer Hospital, Chongqing University, No. 181 Hanyu Road, Shapingba District, Chongqing, 400030, China.; Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, 400030, China., Liu J; Department of Bone and Soft Tissue Tumors, School of Medicine, Chongqing University Cancer Hospital, Chongqing University, No. 181 Hanyu Road, Shapingba District, Chongqing, 400030, China.; Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, 400030, China.; School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China., Tang N; Department of Bone and Soft Tissue Tumors, School of Medicine, Chongqing University Cancer Hospital, Chongqing University, No. 181 Hanyu Road, Shapingba District, Chongqing, 400030, China.; Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, 400030, China.; School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China., Liu WT; Key Laboratory of Biochemistry and Molecular Pharmacology of Chongqing, Chongqing Medical University, Chongqing, 400016, People's Republic of China.; Department of Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, People's Republic of China., Cai J; Key Laboratory of Biochemistry and Molecular Pharmacology of Chongqing, Chongqing Medical University, Chongqing, 400016, People's Republic of China.; Orthopedics Department, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China., He DM; Key Laboratory of Biochemistry and Molecular Pharmacology of Chongqing, Chongqing Medical University, Chongqing, 400016, People's Republic of China.; Department of Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, People's Republic of China., He BC; Key Laboratory of Biochemistry and Molecular Pharmacology of Chongqing, Chongqing Medical University, Chongqing, 400016, People's Republic of China. bche@cqmu.edu.cn.; Department of Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, People's Republic of China. bche@cqmu.edu.cn., He WG; Department of Bone and Soft Tissue Tumors, School of Medicine, Chongqing University Cancer Hospital, Chongqing University, No. 181 Hanyu Road, Shapingba District, Chongqing, 400030, China. cqmu_hwg1995@163.com.; Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, 400030, China. cqmu_hwg1995@163.com., Chen L; Department of Bone and Soft Tissue Tumors, School of Medicine, Chongqing University Cancer Hospital, Chongqing University, No. 181 Hanyu Road, Shapingba District, Chongqing, 400030, China. Chen.liang.1979@cqu.edu.cn.; Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, 400030, China. Chen.liang.1979@cqu.edu.cn.
Source: Stem cell research & therapy [Stem Cell Res Ther] 2026 Jun 26. Date of Electronic Publication: 2026 Jun 26.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1757-6512
DOI:10.1186/s13287-026-05131-0