What is estimated in cluster randomized crossover trials with informative sizes? A survey of estimands and common estimators.

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Title: What is estimated in cluster randomized crossover trials with informative sizes? A survey of estimands and common estimators.
Authors: Lee KM; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA.; Center for Clinical Trials Innovation, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA., Forbes AB; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., Kasza J; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., Copas A; MRC Clinical Trials Unit at UCL, London, UK., Kahan BC; MRC Clinical Trials Unit at UCL, London, UK., Young PJ; Intensive Care Unit, Wellington Hospital, Wellington, New Zealand.; Medical Research Institute of New Zealand, Wellington, New Zealand.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.; Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia., Harhay MO; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA.; Center for Clinical Trials Innovation, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA.; MRC Clinical Trials Unit at UCL, London, UK.; Clinical Trials Methods and Outcomes Lab, Palliative and Advanced Illness Research (PAIR) Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Li F; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.; Center for Methods in Implementation and Prevention Science, Yale School of Public Health, New Haven, CT, USA.
Source: Statistical methods in medical research [Stat Methods Med Res] 2026 Sep; Vol. 35 (9), pp. 1980-2000. Date of Electronic Publication: 2026 Aug 08.
Publication Type: Journal Article
Journal Info: Publisher: SAGE Publications Country of Publication: England NLM ID: 9212457 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0334 (Electronic) Linking ISSN: 09622802 NLM ISO Abbreviation: Stat Methods Med Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1477-0334
DOI:10.1177/09622802261470087