Increased prefrontal hemodynamic change after atomoxetine administration in pediatric attention-deficit/hyperactivity disorder as measured by near-infrared spectroscopy.
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| Title: | Increased prefrontal hemodynamic change after atomoxetine administration in pediatric attention-deficit/hyperactivity disorder as measured by near-infrared spectroscopy. |
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| Authors: | Ota, Toyosaku, Iida, Junzo, Nakanishi, Yoko, Sawada, Satomi, Matsuura, Hiroki, Yamamuro, Kazuhiko, Ueda, Shotaro, Uratani, Mitsuhiro, Kishimoto, Naoko, Negoro, Hideki, Kishimoto, Toshifumi |
| Source: | Psychiatry & Clinical Neurosciences. Mar2015, Vol. 69 Issue 3, p161-170. 10p. 1 Black and White Photograph, 2 Charts, 2 Graphs. |
| Subjects: | Atomoxetine, Treatment of attention-deficit hyperactivity disorder, Noradrenaline, Hemodynamic monitoring, Prefrontal cortex |
| Abstract: | Aim Atomoxetine, approved in Japan for the treatment of pediatric attention-deficit/hyperactivity disorder ( ADHD) in April 2009, is a nonstimulant that is thought to act presynaptically via the inhibition of norepinephrine reuptake. Near-infrared spectroscopy is a non-invasive optical tool that can be used to study oxygenation and hemodynamic changes in the cerebral cortex. The present study examined the effects of a clinical dose of atomoxetine on changes in prefrontal hemodynamic activity in children with ADHD, as measured by near-infrared spectroscopy using the Stroop Color-Word Task. Methods Ten children with ADHD participated in the present study. We used 24-channel near-infrared spectroscopy to measure the relative concentrations of oxyhemoglobin in the frontal lobes of participants in the drug-naïve condition and those who had received atomoxetine for 8 weeks. Measurements were conducted every 0.1 s during the Stroop Color-Word Task. We used the ADHD Rating Scale- IV- Japanese version ( Home Version) to evaluate ADHD symptoms. Results We found a significant decrease in ADHD Rating Scale- IV- Japanese version scores, from 30.7 to 22.6 ( P = 0.003). During the Stroop Color-Word Task, we found significantly higher levels of oxyhemoglobin changes in the prefrontal cortex of participants in the atomoxetine condition compared with those in the drug-naïve condition. Conclusions This increase in oxyhemoglobin changes might indicate an intensified prefrontal hemodynamic response induced by atomoxetine. Near-infrared spectroscopy is a sensitive tool for measuring the pharmacological effects of atomoxetine in children with ADHD. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Aim Atomoxetine, approved in Japan for the treatment of pediatric attention-deficit/hyperactivity disorder ( ADHD) in April 2009, is a nonstimulant that is thought to act presynaptically via the inhibition of norepinephrine reuptake. Near-infrared spectroscopy is a non-invasive optical tool that can be used to study oxygenation and hemodynamic changes in the cerebral cortex. The present study examined the effects of a clinical dose of atomoxetine on changes in prefrontal hemodynamic activity in children with ADHD, as measured by near-infrared spectroscopy using the Stroop Color-Word Task. Methods Ten children with ADHD participated in the present study. We used 24-channel near-infrared spectroscopy to measure the relative concentrations of oxyhemoglobin in the frontal lobes of participants in the drug-naïve condition and those who had received atomoxetine for 8 weeks. Measurements were conducted every 0.1 s during the Stroop Color-Word Task. We used the ADHD Rating Scale- IV- Japanese version ( Home Version) to evaluate ADHD symptoms. Results We found a significant decrease in ADHD Rating Scale- IV- Japanese version scores, from 30.7 to 22.6 ( P = 0.003). During the Stroop Color-Word Task, we found significantly higher levels of oxyhemoglobin changes in the prefrontal cortex of participants in the atomoxetine condition compared with those in the drug-naïve condition. Conclusions This increase in oxyhemoglobin changes might indicate an intensified prefrontal hemodynamic response induced by atomoxetine. Near-infrared spectroscopy is a sensitive tool for measuring the pharmacological effects of atomoxetine in children with ADHD. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 13231316 |
| DOI: | 10.1111/pcn.12251 |
