Increased prefrontal hemodynamic change after atomoxetine administration in pediatric attention-deficit/hyperactivity disorder as measured by near-infrared spectroscopy.
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| Title: | Increased prefrontal hemodynamic change after atomoxetine administration in pediatric attention-deficit/hyperactivity disorder as measured by near-infrared spectroscopy. |
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| Authors: | Ota, Toyosaku, Iida, Junzo, Nakanishi, Yoko, Sawada, Satomi, Matsuura, Hiroki, Yamamuro, Kazuhiko, Ueda, Shotaro, Uratani, Mitsuhiro, Kishimoto, Naoko, Negoro, Hideki, Kishimoto, Toshifumi |
| Source: | Psychiatry & Clinical Neurosciences. Mar2015, Vol. 69 Issue 3, p161-170. 10p. 1 Black and White Photograph, 2 Charts, 2 Graphs. |
| Subjects: | Atomoxetine, Treatment of attention-deficit hyperactivity disorder, Noradrenaline, Hemodynamic monitoring, Prefrontal cortex |
| Abstract: | Aim Atomoxetine, approved in Japan for the treatment of pediatric attention-deficit/hyperactivity disorder ( ADHD) in April 2009, is a nonstimulant that is thought to act presynaptically via the inhibition of norepinephrine reuptake. Near-infrared spectroscopy is a non-invasive optical tool that can be used to study oxygenation and hemodynamic changes in the cerebral cortex. The present study examined the effects of a clinical dose of atomoxetine on changes in prefrontal hemodynamic activity in children with ADHD, as measured by near-infrared spectroscopy using the Stroop Color-Word Task. Methods Ten children with ADHD participated in the present study. We used 24-channel near-infrared spectroscopy to measure the relative concentrations of oxyhemoglobin in the frontal lobes of participants in the drug-naïve condition and those who had received atomoxetine for 8 weeks. Measurements were conducted every 0.1 s during the Stroop Color-Word Task. We used the ADHD Rating Scale- IV- Japanese version ( Home Version) to evaluate ADHD symptoms. Results We found a significant decrease in ADHD Rating Scale- IV- Japanese version scores, from 30.7 to 22.6 ( P = 0.003). During the Stroop Color-Word Task, we found significantly higher levels of oxyhemoglobin changes in the prefrontal cortex of participants in the atomoxetine condition compared with those in the drug-naïve condition. Conclusions This increase in oxyhemoglobin changes might indicate an intensified prefrontal hemodynamic response induced by atomoxetine. Near-infrared spectroscopy is a sensitive tool for measuring the pharmacological effects of atomoxetine in children with ADHD. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 101349371 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Increased prefrontal hemodynamic change after atomoxetine administration in pediatric attention-deficit/hyperactivity disorder as measured by near-infrared spectroscopy. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ota%2C+Toyosaku%22">Ota, Toyosaku</searchLink><br /><searchLink fieldCode="AR" term="%22Iida%2C+Junzo%22">Iida, Junzo</searchLink><br /><searchLink fieldCode="AR" term="%22Nakanishi%2C+Yoko%22">Nakanishi, Yoko</searchLink><br /><searchLink fieldCode="AR" term="%22Sawada%2C+Satomi%22">Sawada, Satomi</searchLink><br /><searchLink fieldCode="AR" term="%22Matsuura%2C+Hiroki%22">Matsuura, Hiroki</searchLink><br /><searchLink fieldCode="AR" term="%22Yamamuro%2C+Kazuhiko%22">Yamamuro, Kazuhiko</searchLink><br /><searchLink fieldCode="AR" term="%22Ueda%2C+Shotaro%22">Ueda, Shotaro</searchLink><br /><searchLink fieldCode="AR" term="%22Uratani%2C+Mitsuhiro%22">Uratani, Mitsuhiro</searchLink><br /><searchLink fieldCode="AR" term="%22Kishimoto%2C+Naoko%22">Kishimoto, Naoko</searchLink><br /><searchLink fieldCode="AR" term="%22Negoro%2C+Hideki%22">Negoro, Hideki</searchLink><br /><searchLink fieldCode="AR" term="%22Kishimoto%2C+Toshifumi%22">Kishimoto, Toshifumi</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. Mar2015, Vol. 69 Issue 3, p161-170. 10p. 1 Black and White Photograph, 2 Charts, 2 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Atomoxetine%22">Atomoxetine</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+of+attention-deficit+hyperactivity+disorder%22">Treatment of attention-deficit hyperactivity disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Noradrenaline%22">Noradrenaline</searchLink><br /><searchLink fieldCode="DE" term="%22Hemodynamic+monitoring%22">Hemodynamic monitoring</searchLink><br /><searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Aim Atomoxetine, approved in Japan for the treatment of pediatric attention-deficit/hyperactivity disorder ( ADHD) in April 2009, is a nonstimulant that is thought to act presynaptically via the inhibition of norepinephrine reuptake. Near-infrared spectroscopy is a non-invasive optical tool that can be used to study oxygenation and hemodynamic changes in the cerebral cortex. The present study examined the effects of a clinical dose of atomoxetine on changes in prefrontal hemodynamic activity in children with ADHD, as measured by near-infrared spectroscopy using the Stroop Color-Word Task. Methods Ten children with ADHD participated in the present study. We used 24-channel near-infrared spectroscopy to measure the relative concentrations of oxyhemoglobin in the frontal lobes of participants in the drug-naïve condition and those who had received atomoxetine for 8 weeks. Measurements were conducted every 0.1 s during the Stroop Color-Word Task. We used the ADHD Rating Scale- IV- Japanese version ( Home Version) to evaluate ADHD symptoms. Results We found a significant decrease in ADHD Rating Scale- IV- Japanese version scores, from 30.7 to 22.6 ( P = 0.003). During the Stroop Color-Word Task, we found significantly higher levels of oxyhemoglobin changes in the prefrontal cortex of participants in the atomoxetine condition compared with those in the drug-naïve condition. Conclusions This increase in oxyhemoglobin changes might indicate an intensified prefrontal hemodynamic response induced by atomoxetine. Near-infrared spectroscopy is a sensitive tool for measuring the pharmacological effects of atomoxetine in children with ADHD. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=101349371 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/pcn.12251 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 161 Subjects: – SubjectFull: Atomoxetine Type: general – SubjectFull: Treatment of attention-deficit hyperactivity disorder Type: general – SubjectFull: Noradrenaline Type: general – SubjectFull: Hemodynamic monitoring Type: general – SubjectFull: Prefrontal cortex Type: general Titles: – TitleFull: Increased prefrontal hemodynamic change after atomoxetine administration in pediatric attention-deficit/hyperactivity disorder as measured by near-infrared spectroscopy. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ota, Toyosaku – PersonEntity: Name: NameFull: Iida, Junzo – PersonEntity: Name: NameFull: Nakanishi, Yoko – PersonEntity: Name: NameFull: Sawada, Satomi – PersonEntity: Name: NameFull: Matsuura, Hiroki – PersonEntity: Name: NameFull: Yamamuro, Kazuhiko – PersonEntity: Name: NameFull: Ueda, Shotaro – PersonEntity: Name: NameFull: Uratani, Mitsuhiro – PersonEntity: Name: NameFull: Kishimoto, Naoko – PersonEntity: Name: NameFull: Negoro, Hideki – PersonEntity: Name: NameFull: Kishimoto, Toshifumi IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 13231316 Numbering: – Type: volume Value: 69 – Type: issue Value: 3 Titles: – TitleFull: Psychiatry & Clinical Neurosciences Type: main |
| ResultId | 1 |
