Bibliographic Details
| Title: |
Family-based association study of DTNBP1 in 6p22.3 and schizophrenia. |
| Authors: |
Tang, J X, Zhou, J, Fan, J B, Li, X W, Shi, Y Y, Gu, N F, Feng, G Y, Xing, Y L, Shi, J G, He, L |
| Source: |
Molecular Psychiatry. 2003, Vol. 8 Issue 8, p717-718. 2p. |
| Subjects: |
Schizophrenia, Etiology of diseases, Epidemiology, Psychoses, Genealogy |
| Abstract: |
The existence of an important genetic contribution to the etiology of schizophrenia is well established from genetic epidemiological studies. The gene of DTNBP1 located on 6p22.3, a high-susceptibility chromosome region of schizophrenia, was highly associated with schizophrenia in Irish high-density pedigrees. DTNBP1, the human ortholog of mouse dysbindin, appears to have a role in neuromuscular synapse formation and maintenance. In the present study, to confirm and extend findings of DTNBP1 in independent samples, researchers investigated seven SNPs within 140-kb length of the gene DTNBP1 in 233 Han Chinese trios. Results showed less heterozygosity in the seven SNPs of DTNBP1 gene compared with the data from a study with Irish high-density pedigrees collected from the relatively homogeneous population of Ireland and Northern Ireland. |
| Database: |
Psychology and Behavioral Sciences Collection |
