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Family-based association study of DTNBP1 in 6p22.3 and schizophrenia.

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Title: Family-based association study of DTNBP1 in 6p22.3 and schizophrenia.
Authors: Tang, J X, Zhou, J, Fan, J B, Li, X W, Shi, Y Y, Gu, N F, Feng, G Y, Xing, Y L, Shi, J G, He, L
Source: Molecular Psychiatry. 2003, Vol. 8 Issue 8, p717-718. 2p.
Subjects: Schizophrenia, Etiology of diseases, Epidemiology, Psychoses, Genealogy
Abstract: The existence of an important genetic contribution to the etiology of schizophrenia is well established from genetic epidemiological studies. The gene of DTNBP1 located on 6p22.3, a high-susceptibility chromosome region of schizophrenia, was highly associated with schizophrenia in Irish high-density pedigrees. DTNBP1, the human ortholog of mouse dysbindin, appears to have a role in neuromuscular synapse formation and maintenance. In the present study, to confirm and extend findings of DTNBP1 in independent samples, researchers investigated seven SNPs within 140-kb length of the gene DTNBP1 in 233 Han Chinese trios. Results showed less heterozygosity in the seven SNPs of DTNBP1 gene compared with the data from a study with Irish high-density pedigrees collected from the relatively homogeneous population of Ireland and Northern Ireland.
Database: Psychology and Behavioral Sciences Collection
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  Data: Family-based association study of DTNBP1 in 6p22.3 and schizophrenia.
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  Data: <searchLink fieldCode="AR" term="%22Tang%2C+J+X%22">Tang, J X</searchLink><br /><searchLink fieldCode="AR" term="%22Zhou%2C+J%22">Zhou, J</searchLink><br /><searchLink fieldCode="AR" term="%22Fan%2C+J+B%22">Fan, J B</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+X+W%22">Li, X W</searchLink><br /><searchLink fieldCode="AR" term="%22Shi%2C+Y+Y%22">Shi, Y Y</searchLink><br /><searchLink fieldCode="AR" term="%22Gu%2C+N+F%22">Gu, N F</searchLink><br /><searchLink fieldCode="AR" term="%22Feng%2C+G+Y%22">Feng, G Y</searchLink><br /><searchLink fieldCode="AR" term="%22Xing%2C+Y+L%22">Xing, Y L</searchLink><br /><searchLink fieldCode="AR" term="%22Shi%2C+J+G%22">Shi, J G</searchLink><br /><searchLink fieldCode="AR" term="%22He%2C+L%22">He, L</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. 2003, Vol. 8 Issue 8, p717-718. 2p.
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  Data: <searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Etiology+of+diseases%22">Etiology of diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Epidemiology%22">Epidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Genealogy%22">Genealogy</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The existence of an important genetic contribution to the etiology of schizophrenia is well established from genetic epidemiological studies. The gene of DTNBP1 located on 6p22.3, a high-susceptibility chromosome region of schizophrenia, was highly associated with schizophrenia in Irish high-density pedigrees. DTNBP1, the human ortholog of mouse dysbindin, appears to have a role in neuromuscular synapse formation and maintenance. In the present study, to confirm and extend findings of DTNBP1 in independent samples, researchers investigated seven SNPs within 140-kb length of the gene DTNBP1 in 233 Han Chinese trios. Results showed less heterozygosity in the seven SNPs of DTNBP1 gene compared with the data from a study with Irish high-density pedigrees collected from the relatively homogeneous population of Ireland and Northern Ireland.
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        Value: 10.1038/sj.mp.4001287
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        Text: English
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      – SubjectFull: Schizophrenia
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      – SubjectFull: Epidemiology
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      – SubjectFull: Psychoses
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              M: 08
              Text: 2003
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              Y: 2003
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