Association between interleukin-6 gene promoter -572C/G polymorphism and the risk of sporadic Alzheimer's disease.

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Title:	Association between interleukin-6 gene promoter -572C/G polymorphism and the risk of sporadic Alzheimer's disease.
Authors:	He MX (AUTHOR), Yang WL (AUTHOR), Zhang MM (AUTHOR), Lian YJ (AUTHOR), Hua HY (AUTHOR), Zeng JS (AUTHOR), Zhang LR (AUTHOR), He, Mei-xia (AUTHOR), Yang, Wan-li (AUTHOR), Zhang, Ming-ming (AUTHOR), Lian, Ya-jun (AUTHOR), Hua, Hai-ying (AUTHOR), Zeng, Jin-sheng (AUTHOR), Zhang, Li-rong (AUTHOR)
Source:	Neurological Sciences. Apr2010, Vol. 31 Issue 2, p165-168. 4p.
Abstract:	Inflammation is a key component of Alzheimer's disease (AD), and we have examined the effect of two polymorphisms (-174G/C and -572C/G) in the promoter of the inflammatory cytokine interleukin-6 (IL-6) gene on risk of AD in 318 AD patients. Significant differences in genotype and allele frequencies of -572C/G IL-6 promoter polymorphism were observed between AD patients and controls. The GG genotype was associated with a decreased risk of developing AD (OR 0.423, 95% CI 0.200-0.894). Similarly, logistic regression analysis revealed that G allele was a protective factor for AD (OR 0.732, 95% CI 0.567-0.945). For -174G/C variability, no C variability was found in all the subjects. The frequency of the IL-6 -174G/C promoter polymorphism is very low or no variability in Henan Han population. The -572C/G polymorphism of IL-6 gene promoter region is associated with AD, and G allele is an independent protective factor for AD. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	Inflammation is a key component of Alzheimer's disease (AD), and we have examined the effect of two polymorphisms (-174G/C and -572C/G) in the promoter of the inflammatory cytokine interleukin-6 (IL-6) gene on risk of AD in 318 AD patients. Significant differences in genotype and allele frequencies of -572C/G IL-6 promoter polymorphism were observed between AD patients and controls. The GG genotype was associated with a decreased risk of developing AD (OR 0.423, 95% CI 0.200-0.894). Similarly, logistic regression analysis revealed that G allele was a protective factor for AD (OR 0.732, 95% CI 0.567-0.945). For -174G/C variability, no C variability was found in all the subjects. The frequency of the IL-6 -174G/C promoter polymorphism is very low or no variability in Henan Han population. The -572C/G polymorphism of IL-6 gene promoter region is associated with AD, and G allele is an independent protective factor for AD. [ABSTRACT FROM AUTHOR]
ISSN:	15901874
DOI:	10.1007/s10072-009-0199-3