Bibliographic Details
| Title: |
mRNA and protein levels for GABA A alpha4, alpha5, beta1 and GABA B R1 receptors are altered in brains from subjects with autism. |
| Authors: |
Fatemi SH (AUTHOR), Reutiman TJ (AUTHOR), Folsom TD (AUTHOR), Rooney RJ (AUTHOR), Patel DH (AUTHOR), Thuras PD (AUTHOR) |
| Source: |
Journal of Autism & Developmental Disorders. Jun2010, Vol. 40 Issue 6, p743-750. 8p. |
| Abstract: |
We have shown altered expression of gamma-aminobutyric acid A (GABAA) and gamma-aminobutyric acid B (GABAB) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABAA subunits previously associated with autism (GABR[alpha]4; GABR[alpha]5; GABR[beta]1). Three GABA receptor subunits demonstrated mRNA and protein level concordance in superior frontal cortex (GABR[alpha]4, GABR[alpha]5, GABR[beta]1) and one demonstrated concordance in cerebellum (GAB[Beta]R1). These results provide further evidence of impairment of GABAergic signaling in autism. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
