mRNA and protein levels for GABA A alpha4, alpha5, beta1 and GABA B R1 receptors are altered in brains from subjects with autism.
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| Title: | mRNA and protein levels for GABA A alpha4, alpha5, beta1 and GABA B R1 receptors are altered in brains from subjects with autism. |
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| Authors: | Fatemi SH (AUTHOR), Reutiman TJ (AUTHOR), Folsom TD (AUTHOR), Rooney RJ (AUTHOR), Patel DH (AUTHOR), Thuras PD (AUTHOR) |
| Source: | Journal of Autism & Developmental Disorders. Jun2010, Vol. 40 Issue 6, p743-750. 8p. |
| Abstract: | We have shown altered expression of gamma-aminobutyric acid A (GABAA) and gamma-aminobutyric acid B (GABAB) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABAA subunits previously associated with autism (GABR[alpha]4; GABR[alpha]5; GABR[beta]1). Three GABA receptor subunits demonstrated mRNA and protein level concordance in superior frontal cortex (GABR[alpha]4, GABR[alpha]5, GABR[beta]1) and one demonstrated concordance in cerebellum (GAB[Beta]R1). These results provide further evidence of impairment of GABAergic signaling in autism. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 105195878 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: mRNA and protein levels for GABA A alpha4, alpha5, beta1 and GABA B R1 receptors are altered in brains from subjects with autism. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fatemi+SH%22">Fatemi SH</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reutiman+TJ%22">Reutiman TJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Folsom+TD%22">Folsom TD</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rooney+RJ%22">Rooney RJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Patel+DH%22">Patel DH</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thuras+PD%22">Thuras PD</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Autism+%26+Developmental+Disorders%22">Journal of Autism & Developmental Disorders</searchLink>. Jun2010, Vol. 40 Issue 6, p743-750. 8p. – Name: Abstract Label: Abstract Group: Ab Data: We have shown altered expression of gamma-aminobutyric acid A (GABAA) and gamma-aminobutyric acid B (GABAB) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABAA subunits previously associated with autism (GABR[alpha]4; GABR[alpha]5; GABR[beta]1). Three GABA receptor subunits demonstrated mRNA and protein level concordance in superior frontal cortex (GABR[alpha]4, GABR[alpha]5, GABR[beta]1) and one demonstrated concordance in cerebellum (GAB[Beta]R1). These results provide further evidence of impairment of GABAergic signaling in autism. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=105195878 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10803-009-0924-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 743 Titles: – TitleFull: mRNA and protein levels for GABA A alpha4, alpha5, beta1 and GABA B R1 receptors are altered in brains from subjects with autism. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fatemi SH – PersonEntity: Name: NameFull: Reutiman TJ – PersonEntity: Name: NameFull: Folsom TD – PersonEntity: Name: NameFull: Rooney RJ – PersonEntity: Name: NameFull: Patel DH – PersonEntity: Name: NameFull: Thuras PD IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 01623257 Numbering: – Type: volume Value: 40 – Type: issue Value: 6 Titles: – TitleFull: Journal of Autism & Developmental Disorders Type: main |
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