Prevalence of hepatitis B, tetanus, hepatitis A, human immunodeficiency virus and feasibility of vaccine delivery among injecting drug users in Bangkok, Thailand, 2003-2005.

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Title:	Prevalence of hepatitis B, tetanus, hepatitis A, human immunodeficiency virus and feasibility of vaccine delivery among injecting drug users in Bangkok, Thailand, 2003-2005.
Authors:	Sunthornchart S (AUTHOR), Linkins RW (AUTHOR), Natephisarnwanish V (AUTHOR), Levine WC (AUTHOR), Maneesinthu K (AUTHOR), Lolekha R (AUTHOR), Tappero JW (AUTHOR), Trirat N (AUTHOR), Muktier S (AUTHOR), Chancharastong P (AUTHOR), Fox K (AUTHOR), Donchalermpak S (AUTHOR), Vitek C (AUTHOR), Supawitkul S (AUTHOR)
Source:	Addiction. Oct2008, Vol. 103 Issue 10, p1687-1695. 9p.
Abstract:	OBJECTIVES: To estimate the prevalence of hepatitis B virus (HBV), tetanus, hepatitis A virus (HAV) and human immunodeficiency virus (HIV) in injecting drug users (IDUs), risk factors associated with infection and the feasibility of HBV vaccine delivery in HBV seronegatives. METHODS: Cross-sectional seroprevalence survey of 1535 IDUs recruited from 17 Bangkok Metropolitan Administration (BMA) methadone clinics and HBV vaccination of seronegatives. RESULTS: Prevalence of antibody to HBV, tetanus, HAV and HIV was 87.8%, 68.1%, 60.2% and 35.9%, respectively. Prevalence of HBV and HAV increased with increasing age; prevalence of tetanus decreased with increasing age. Being HIV seropositive was related inversely to income and being tetanus seronegative. Of the 189 HBV seronegative IDUs, 81.0% completed the vaccine series. IDUs with HIV had a 6.5-fold odds of vaccine non-response. CONCLUSIONS: These data underscore the need for, and feasibility of, vaccine delivery in this population and support targeting efforts at high-risk age groups. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	OBJECTIVES: To estimate the prevalence of hepatitis B virus (HBV), tetanus, hepatitis A virus (HAV) and human immunodeficiency virus (HIV) in injecting drug users (IDUs), risk factors associated with infection and the feasibility of HBV vaccine delivery in HBV seronegatives. METHODS: Cross-sectional seroprevalence survey of 1535 IDUs recruited from 17 Bangkok Metropolitan Administration (BMA) methadone clinics and HBV vaccination of seronegatives. RESULTS: Prevalence of antibody to HBV, tetanus, HAV and HIV was 87.8%, 68.1%, 60.2% and 35.9%, respectively. Prevalence of HBV and HAV increased with increasing age; prevalence of tetanus decreased with increasing age. Being HIV seropositive was related inversely to income and being tetanus seronegative. Of the 189 HBV seronegative IDUs, 81.0% completed the vaccine series. IDUs with HIV had a 6.5-fold odds of vaccine non-response. CONCLUSIONS: These data underscore the need for, and feasibility of, vaccine delivery in this population and support targeting efforts at high-risk age groups. [ABSTRACT FROM AUTHOR]
ISSN:	09652140
DOI:	10.1111/j.1360-0443.2008.02303.x