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Cardiovascular status of infants and children of women infected with HIV-1 (P(2)C(2) HIV): a cohort study.

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Title: Cardiovascular status of infants and children of women infected with HIV-1 (P(2)C(2) HIV): a cohort study.
Authors: Lipschultz SE (AUTHOR), Easley KA (AUTHOR), Orav EJ (AUTHOR), Kaplan S (AUTHOR), Starc TJ (AUTHOR), Bricker JT (AUTHOR), Lai WW (AUTHOR), Moodie DS (AUTHOR), Sopko G (AUTHOR), Schluchter MD (AUTHOR), Colan SD (AUTHOR), Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study Group (CORPORATE AUTHOR), Lipshultz, Steven E (AUTHOR), Easley, Kirk A (AUTHOR), Orav, E John (AUTHOR), Kaplan, Samuel (AUTHOR), Starc, Thomas J (AUTHOR), Bricker, J Timothy (AUTHOR), Lai, Wyman W (AUTHOR), Moodie, Douglas S (AUTHOR)
Source: Lancet. 8/3/2002, Vol. 360 Issue 9330, p368-373. 6p.
Abstract: Background: Data from cross-sectional and short-term longitudinal studies have suggested that children infected with HIV-1 might have cardiovascular abnormalities. We aimed to investigate this hypothesis in a long-term cohort study.Methods: We measured cardiovascular function every 4-6 months for up to 5 years in a birth cohort of 600 infants born to women infected with HIV-1. We included 93 infants infected with HIV-1 and 463 uninfected infants (internal controls) from the same cohort. We also included a cross-sectionally measured comparison group of 195 healthy children born to mothers who were not infected with HIV-1 (external controls).Findings: Children infected with HIV-1 had a significantly higher heart rate at all ages (mean difference 10 bpm, 95% CI 8-13) than internal controls. At birth, both cohort groups of children had similar low left ventricular (LV) fractional shortening. At 8 months, fractional shortening was similar in internal and external controls, whereas in children infected with HIV-1, fractional shortening remained significantly lower than in controls for the first 20 months of life (mean difference from internal controls at 8 months 3.7%, 2.3-5.1). LV mass was similar at birth in both cohort groups, but became significantly higher in children with HIV-1 from 4-30 months (mean difference 2.4 g at 8 months, 0.9-3.9).Conclusions: Vertically-transmitted HIV-1 infection is associated with persistent cardiovascular abnormalities identifiable shortly after birth. Irrespective of their HIV-1 status, infants born to women infected with HIV-1 have significantly worse cardiac function than other infants, suggesting that the uterine environment has an important role in postnatal cardiovascular abnormalities. [ABSTRACT FROM AUTHOR]
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Database: Psychology and Behavioral Sciences Collection
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Abstract:<bold>Background: </bold>Data from cross-sectional and short-term longitudinal studies have suggested that children infected with HIV-1 might have cardiovascular abnormalities. We aimed to investigate this hypothesis in a long-term cohort study.<bold>Methods: </bold>We measured cardiovascular function every 4-6 months for up to 5 years in a birth cohort of 600 infants born to women infected with HIV-1. We included 93 infants infected with HIV-1 and 463 uninfected infants (internal controls) from the same cohort. We also included a cross-sectionally measured comparison group of 195 healthy children born to mothers who were not infected with HIV-1 (external controls).<bold>Findings: </bold>Children infected with HIV-1 had a significantly higher heart rate at all ages (mean difference 10 bpm, 95% CI 8-13) than internal controls. At birth, both cohort groups of children had similar low left ventricular (LV) fractional shortening. At 8 months, fractional shortening was similar in internal and external controls, whereas in children infected with HIV-1, fractional shortening remained significantly lower than in controls for the first 20 months of life (mean difference from internal controls at 8 months 3.7%, 2.3-5.1). LV mass was similar at birth in both cohort groups, but became significantly higher in children with HIV-1 from 4-30 months (mean difference 2.4 g at 8 months, 0.9-3.9).<bold>Conclusions: </bold>Vertically-transmitted HIV-1 infection is associated with persistent cardiovascular abnormalities identifiable shortly after birth. Irrespective of their HIV-1 status, infants born to women infected with HIV-1 have significantly worse cardiac function than other infants, suggesting that the uterine environment has an important role in postnatal cardiovascular abnormalities. [ABSTRACT FROM AUTHOR]
ISSN:01406736