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Cardiovascular status of infants and children of women infected with HIV-1 (P(2)C(2) HIV): a cohort study.

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Title: Cardiovascular status of infants and children of women infected with HIV-1 (P(2)C(2) HIV): a cohort study.
Authors: Lipschultz SE (AUTHOR), Easley KA (AUTHOR), Orav EJ (AUTHOR), Kaplan S (AUTHOR), Starc TJ (AUTHOR), Bricker JT (AUTHOR), Lai WW (AUTHOR), Moodie DS (AUTHOR), Sopko G (AUTHOR), Schluchter MD (AUTHOR), Colan SD (AUTHOR), Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study Group (CORPORATE AUTHOR), Lipshultz, Steven E (AUTHOR), Easley, Kirk A (AUTHOR), Orav, E John (AUTHOR), Kaplan, Samuel (AUTHOR), Starc, Thomas J (AUTHOR), Bricker, J Timothy (AUTHOR), Lai, Wyman W (AUTHOR), Moodie, Douglas S (AUTHOR)
Source: Lancet. 8/3/2002, Vol. 360 Issue 9330, p368-373. 6p.
Abstract: Background: Data from cross-sectional and short-term longitudinal studies have suggested that children infected with HIV-1 might have cardiovascular abnormalities. We aimed to investigate this hypothesis in a long-term cohort study.Methods: We measured cardiovascular function every 4-6 months for up to 5 years in a birth cohort of 600 infants born to women infected with HIV-1. We included 93 infants infected with HIV-1 and 463 uninfected infants (internal controls) from the same cohort. We also included a cross-sectionally measured comparison group of 195 healthy children born to mothers who were not infected with HIV-1 (external controls).Findings: Children infected with HIV-1 had a significantly higher heart rate at all ages (mean difference 10 bpm, 95% CI 8-13) than internal controls. At birth, both cohort groups of children had similar low left ventricular (LV) fractional shortening. At 8 months, fractional shortening was similar in internal and external controls, whereas in children infected with HIV-1, fractional shortening remained significantly lower than in controls for the first 20 months of life (mean difference from internal controls at 8 months 3.7%, 2.3-5.1). LV mass was similar at birth in both cohort groups, but became significantly higher in children with HIV-1 from 4-30 months (mean difference 2.4 g at 8 months, 0.9-3.9).Conclusions: Vertically-transmitted HIV-1 infection is associated with persistent cardiovascular abnormalities identifiable shortly after birth. Irrespective of their HIV-1 status, infants born to women infected with HIV-1 have significantly worse cardiac function than other infants, suggesting that the uterine environment has an important role in postnatal cardiovascular abnormalities. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Cardiovascular status of infants and children of women infected with HIV-1 (P(2)C(2) HIV): a cohort study.
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  Data: <searchLink fieldCode="AR" term="%22Lipschultz+SE%22">Lipschultz SE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Easley+KA%22">Easley KA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Orav+EJ%22">Orav EJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kaplan+S%22">Kaplan S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Starc+TJ%22">Starc TJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bricker+JT%22">Bricker JT</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lai+WW%22">Lai WW</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moodie+DS%22">Moodie DS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sopko+G%22">Sopko G</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schluchter+MD%22">Schluchter MD</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Colan+SD%22">Colan SD</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pediatric+Pulmonary+and+Cardiovascular+Complications+of+Vertically+Transmitted+HIV+Infection+Study+Group%22">Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study Group</searchLink> (CORPORATE AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lipshultz%2C+Steven+E%22">Lipshultz, Steven E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Easley%2C+Kirk+A%22">Easley, Kirk A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Orav%2C+E+John%22">Orav, E John</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kaplan%2C+Samuel%22">Kaplan, Samuel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Starc%2C+Thomas+J%22">Starc, Thomas J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bricker%2C+J+Timothy%22">Bricker, J Timothy</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lai%2C+Wyman+W%22">Lai, Wyman W</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moodie%2C+Douglas+S%22">Moodie, Douglas S</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 8/3/2002, Vol. 360 Issue 9330, p368-373. 6p.
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  Data: <bold>Background: </bold>Data from cross-sectional and short-term longitudinal studies have suggested that children infected with HIV-1 might have cardiovascular abnormalities. We aimed to investigate this hypothesis in a long-term cohort study.<bold>Methods: </bold>We measured cardiovascular function every 4-6 months for up to 5 years in a birth cohort of 600 infants born to women infected with HIV-1. We included 93 infants infected with HIV-1 and 463 uninfected infants (internal controls) from the same cohort. We also included a cross-sectionally measured comparison group of 195 healthy children born to mothers who were not infected with HIV-1 (external controls).<bold>Findings: </bold>Children infected with HIV-1 had a significantly higher heart rate at all ages (mean difference 10 bpm, 95% CI 8-13) than internal controls. At birth, both cohort groups of children had similar low left ventricular (LV) fractional shortening. At 8 months, fractional shortening was similar in internal and external controls, whereas in children infected with HIV-1, fractional shortening remained significantly lower than in controls for the first 20 months of life (mean difference from internal controls at 8 months 3.7%, 2.3-5.1). LV mass was similar at birth in both cohort groups, but became significantly higher in children with HIV-1 from 4-30 months (mean difference 2.4 g at 8 months, 0.9-3.9).<bold>Conclusions: </bold>Vertically-transmitted HIV-1 infection is associated with persistent cardiovascular abnormalities identifiable shortly after birth. Irrespective of their HIV-1 status, infants born to women infected with HIV-1 have significantly worse cardiac function than other infants, suggesting that the uterine environment has an important role in postnatal cardiovascular abnormalities. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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