Prescription Stimulants and PTSD Among U.S. Military Service Members.

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Bibliographic Details
Title: Prescription Stimulants and PTSD Among U.S. Military Service Members.
Authors: Crum‐Cianflone, Nancy F., Frasco, Melissa A., Armenta, Richard F., Phillips, Christopher J., Horton, Jaime, Ryan, Margaret A. K., Russell, Dale W., LeardMann, Cynthia, Crum-Cianflone, Nancy F (AUTHOR)
Source: Journal of Traumatic Stress. Dec2015, Vol. 28 Issue 6, p585-589. 5p. 2 Charts.
Subjects: Post-traumatic stress disorder, Diseases in military personnel, Drug prescribing, Stimulants, Secondary analysis, Therapeutics, Pharmacokinetics, Diagnosis of post-traumatic stress disorder, Drug therapy, Attention-deficit hyperactivity disorder, Demography, Drugs, Research funding, Military personnel, Psychology of military personnel, Comorbidity, Disease incidence, Central nervous system stimulants, Proportional hazards models
Geographic Terms: United States
Abstract: Posttraumatic stress disorder (PTSD) is a prevalent condition among military service members and civilians who have experienced traumatic events. Stimulant use has been postulated to increase the risk of incident PTSD; however, research in this area is lacking. In this study, the association between receipt of prescription stimulants and PTSD was examined in a secondary analysis among active duty U.S. military members (n = 25,971), participating in the Millennium Cohort Study, who completed a baseline (2001-2003) and two follow-up surveys (between 2004-2008). Prescription stimulant data were obtained from the military Pharmacy Data Transaction Service. PTSD was assessed using the PTSD Checklist-Civilian Version and incident PTSD was defined as meeting the criteria at follow-up among those who did not have a history of PTSD at baseline. Overall, 1,215 (4.7%) persons developed new-onset PTSD during follow-up. Receipt of prescription stimulants were significantly associated with incident PTSD, hazard ratio = 5.09, 95% confidence interval [3.05, 8.50], after adjusting for sociodemographic factors, military characteristics, attention-deficit/hyperactivity disorder, baseline mental and physical health status, deployment experiences, and physical/sexual trauma. Findings suggested that prescription stimulants are associated with incident PTSD among military personnel; these data may inform the underlying pathogenesis of and preventive strategies for PTSD. [ABSTRACT FROM AUTHOR]
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Database: Psychology and Behavioral Sciences Collection
Description
Abstract:Posttraumatic stress disorder (PTSD) is a prevalent condition among military service members and civilians who have experienced traumatic events. Stimulant use has been postulated to increase the risk of incident PTSD; however, research in this area is lacking. In this study, the association between receipt of prescription stimulants and PTSD was examined in a secondary analysis among active duty U.S. military members (n = 25,971), participating in the Millennium Cohort Study, who completed a baseline (2001-2003) and two follow-up surveys (between 2004-2008). Prescription stimulant data were obtained from the military Pharmacy Data Transaction Service. PTSD was assessed using the PTSD Checklist-Civilian Version and incident PTSD was defined as meeting the criteria at follow-up among those who did not have a history of PTSD at baseline. Overall, 1,215 (4.7%) persons developed new-onset PTSD during follow-up. Receipt of prescription stimulants were significantly associated with incident PTSD, hazard ratio = 5.09, 95% confidence interval [3.05, 8.50], after adjusting for sociodemographic factors, military characteristics, attention-deficit/hyperactivity disorder, baseline mental and physical health status, deployment experiences, and physical/sexual trauma. Findings suggested that prescription stimulants are associated with incident PTSD among military personnel; these data may inform the underlying pathogenesis of and preventive strategies for PTSD. [ABSTRACT FROM AUTHOR]
ISSN:08949867
DOI:10.1002/jts.22052