Prescription Stimulants and PTSD Among U.S. Military Service Members.

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Title: Prescription Stimulants and PTSD Among U.S. Military Service Members.
Authors: Crum‐Cianflone, Nancy F., Frasco, Melissa A., Armenta, Richard F., Phillips, Christopher J., Horton, Jaime, Ryan, Margaret A. K., Russell, Dale W., LeardMann, Cynthia, Crum-Cianflone, Nancy F (AUTHOR)
Source: Journal of Traumatic Stress. Dec2015, Vol. 28 Issue 6, p585-589. 5p. 2 Charts.
Subjects: Post-traumatic stress disorder, Diseases in military personnel, Drug prescribing, Stimulants, Secondary analysis, Therapeutics, Pharmacokinetics, Diagnosis of post-traumatic stress disorder, Drug therapy, Attention-deficit hyperactivity disorder, Demography, Drugs, Research funding, Military personnel, Psychology of military personnel, Comorbidity, Disease incidence, Central nervous system stimulants, Proportional hazards models
Geographic Terms: United States
Abstract: Posttraumatic stress disorder (PTSD) is a prevalent condition among military service members and civilians who have experienced traumatic events. Stimulant use has been postulated to increase the risk of incident PTSD; however, research in this area is lacking. In this study, the association between receipt of prescription stimulants and PTSD was examined in a secondary analysis among active duty U.S. military members (n = 25,971), participating in the Millennium Cohort Study, who completed a baseline (2001-2003) and two follow-up surveys (between 2004-2008). Prescription stimulant data were obtained from the military Pharmacy Data Transaction Service. PTSD was assessed using the PTSD Checklist-Civilian Version and incident PTSD was defined as meeting the criteria at follow-up among those who did not have a history of PTSD at baseline. Overall, 1,215 (4.7%) persons developed new-onset PTSD during follow-up. Receipt of prescription stimulants were significantly associated with incident PTSD, hazard ratio = 5.09, 95% confidence interval [3.05, 8.50], after adjusting for sociodemographic factors, military characteristics, attention-deficit/hyperactivity disorder, baseline mental and physical health status, deployment experiences, and physical/sexual trauma. Findings suggested that prescription stimulants are associated with incident PTSD among military personnel; these data may inform the underlying pathogenesis of and preventive strategies for PTSD. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Traumatic Stress is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Prescription Stimulants and PTSD Among U.S. Military Service Members.
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  Data: <searchLink fieldCode="AR" term="%22Crum‐Cianflone%2C+Nancy+F%2E%22">Crum‐Cianflone, Nancy F.</searchLink><br /><searchLink fieldCode="AR" term="%22Frasco%2C+Melissa+A%2E%22">Frasco, Melissa A.</searchLink><br /><searchLink fieldCode="AR" term="%22Armenta%2C+Richard+F%2E%22">Armenta, Richard F.</searchLink><br /><searchLink fieldCode="AR" term="%22Phillips%2C+Christopher+J%2E%22">Phillips, Christopher J.</searchLink><br /><searchLink fieldCode="AR" term="%22Horton%2C+Jaime%22">Horton, Jaime</searchLink><br /><searchLink fieldCode="AR" term="%22Ryan%2C+Margaret+A%2E+K%2E%22">Ryan, Margaret A. K.</searchLink><br /><searchLink fieldCode="AR" term="%22Russell%2C+Dale+W%2E%22">Russell, Dale W.</searchLink><br /><searchLink fieldCode="AR" term="%22LeardMann%2C+Cynthia%22">LeardMann, Cynthia</searchLink><br /><searchLink fieldCode="AR" term="%22Crum-Cianflone%2C+Nancy+F%22">Crum-Cianflone, Nancy F</searchLink> (AUTHOR)
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  Data: Posttraumatic stress disorder (PTSD) is a prevalent condition among military service members and civilians who have experienced traumatic events. Stimulant use has been postulated to increase the risk of incident PTSD; however, research in this area is lacking. In this study, the association between receipt of prescription stimulants and PTSD was examined in a secondary analysis among active duty U.S. military members (n = 25,971), participating in the Millennium Cohort Study, who completed a baseline (2001-2003) and two follow-up surveys (between 2004-2008). Prescription stimulant data were obtained from the military Pharmacy Data Transaction Service. PTSD was assessed using the PTSD Checklist-Civilian Version and incident PTSD was defined as meeting the criteria at follow-up among those who did not have a history of PTSD at baseline. Overall, 1,215 (4.7%) persons developed new-onset PTSD during follow-up. Receipt of prescription stimulants were significantly associated with incident PTSD, hazard ratio = 5.09, 95% confidence interval [3.05, 8.50], after adjusting for sociodemographic factors, military characteristics, attention-deficit/hyperactivity disorder, baseline mental and physical health status, deployment experiences, and physical/sexual trauma. Findings suggested that prescription stimulants are associated with incident PTSD among military personnel; these data may inform the underlying pathogenesis of and preventive strategies for PTSD. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Traumatic Stress is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=111472995
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      – Type: doi
        Value: 10.1002/jts.22052
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        Text: English
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        PageCount: 5
        StartPage: 585
    Subjects:
      – SubjectFull: Post-traumatic stress disorder
        Type: general
      – SubjectFull: Diseases in military personnel
        Type: general
      – SubjectFull: Drug prescribing
        Type: general
      – SubjectFull: Stimulants
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      – SubjectFull: Secondary analysis
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      – SubjectFull: Therapeutics
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      – SubjectFull: Pharmacokinetics
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      – SubjectFull: Diagnosis of post-traumatic stress disorder
        Type: general
      – SubjectFull: Drug therapy
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      – SubjectFull: Attention-deficit hyperactivity disorder
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      – SubjectFull: Demography
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      – SubjectFull: Drugs
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      – SubjectFull: Research funding
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      – SubjectFull: Military personnel
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      – SubjectFull: Psychology of military personnel
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      – SubjectFull: Comorbidity
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      – SubjectFull: Disease incidence
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      – SubjectFull: Central nervous system stimulants
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      – SubjectFull: Proportional hazards models
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      – SubjectFull: United States
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      – TitleFull: Prescription Stimulants and PTSD Among U.S. Military Service Members.
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              Text: Dec2015
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