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Using admixture analysis to examine birth-cohort effects on age at onset of bipolar disorder.

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Title: Using admixture analysis to examine birth-cohort effects on age at onset of bipolar disorder.
Authors: Golmard, J.‐L., Scott, J., Etain, B., Preisig, M., Aubry, J.‐M., Henry, C., Jamain, S., Azorin, J.‐M., Leboyer, M., Bellivier, F.
Source: Acta Psychiatrica Scandinavica. Mar2016, Vol. 133 Issue 3, p205-213. 9p. 2 Charts, 1 Graph.
Subjects: Psychiatric research, Age of onset, Age factors in disease, Bipolar disorder, Mania
Abstract: Objective It is suggested that age at onset ( AAO) of bipolar I disorder ( BP-I) is decreasing. We tested for a birth-cohort effect on AAO using admixture analysis. Method A clinical sample of 3896 BP-I cases was analysed using two approaches: (i) in a subsample with untruncated AAO × birth year distribution ( n = 1865), we compared the best-fitting model for the observed AAO in patients born ≤1960 and >1960, (ii) to control for potential confounders, two separate subsamples born ≤1960 and >1960 were matched for age at interview ( n = 250), and a further admixture analysis was undertaken. Results The two approaches indicated that the proportion of cases in the early AAO category was significantly greater in cases born >1960; manic onsets were also more frequent in the early onset BP-I cases born >1960. Conclusion The decrease in AAO of BP-I in recent birth-cohorts appears to be associated with an increase in the proportion of cases in the early onset subgroup; not with a decrease in the mean AAO in each putative subgroup. This could indicate temporal changes in exposure to risk factors for mania. [ABSTRACT FROM AUTHOR]
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Database: Psychology and Behavioral Sciences Collection
Description
Abstract:Objective It is suggested that age at onset ( AAO) of bipolar I disorder ( BP-I) is decreasing. We tested for a birth-cohort effect on AAO using admixture analysis. Method A clinical sample of 3896 BP-I cases was analysed using two approaches: (i) in a subsample with untruncated AAO × birth year distribution ( n = 1865), we compared the best-fitting model for the observed AAO in patients born ≤1960 and >1960, (ii) to control for potential confounders, two separate subsamples born ≤1960 and >1960 were matched for age at interview ( n = 250), and a further admixture analysis was undertaken. Results The two approaches indicated that the proportion of cases in the early AAO category was significantly greater in cases born >1960; manic onsets were also more frequent in the early onset BP-I cases born >1960. Conclusion The decrease in AAO of BP-I in recent birth-cohorts appears to be associated with an increase in the proportion of cases in the early onset subgroup; not with a decrease in the mean AAO in each putative subgroup. This could indicate temporal changes in exposure to risk factors for mania. [ABSTRACT FROM AUTHOR]
ISSN:0001690X
DOI:10.1111/acps.12478