CMAP decrement as a potential diagnostic marker for ALS.
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| Title: | CMAP decrement as a potential diagnostic marker for ALS. |
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| Authors: | Mori, A., Yamashita, S., Nakajima, M., Hori, H., Tawara, A., Matsuo, Y., Misumi, Y., Ando, Y. |
| Source: | Acta Neurologica Scandinavica. Jul2016, Vol. 134 Issue 1, p49-53. 5p. |
| Subjects: | Amyotrophic lateral sclerosis, Action potentials, Neural stimulation, Biomarkers, Pathological physiology, Diagnosis |
| Abstract: | Objective We previously reported that decrement of compound muscle action potential (CMAP) by repetitive nerve stimulation (RNS) was greater in the median nerves than in the ulnar nerves of patients with amyotrophic lateral sclerosis (ALS). The aim of this study was to evaluate whether CMAP decrement by RNS is a feasible marker for the differentiation of ALS from other diseases. Materials & methods We performed RNS in the median and ulnar nerves of 51 patients with ALS and 40 patients with other diseases. Results The CMAP decrement was significantly greater in the median nerves of patients with ALS, compared to the disease control patients. In the median nerves of patients with ALS, CMAP decrement was significantly greater in the cervical region-onset group than in the other region-onset group. Conclusions The finding of CMAP decrement in the median nerves can be useful for differentiating ALS patients with cervical region onset from other controls with active neuropathic diseases. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Objective We previously reported that decrement of compound muscle action potential (CMAP) by repetitive nerve stimulation (RNS) was greater in the median nerves than in the ulnar nerves of patients with amyotrophic lateral sclerosis (ALS). The aim of this study was to evaluate whether CMAP decrement by RNS is a feasible marker for the differentiation of ALS from other diseases. Materials & methods We performed RNS in the median and ulnar nerves of 51 patients with ALS and 40 patients with other diseases. Results The CMAP decrement was significantly greater in the median nerves of patients with ALS, compared to the disease control patients. In the median nerves of patients with ALS, CMAP decrement was significantly greater in the cervical region-onset group than in the other region-onset group. Conclusions The finding of CMAP decrement in the median nerves can be useful for differentiating ALS patients with cervical region onset from other controls with active neuropathic diseases. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00016314 |
| DOI: | 10.1111/ane.12510 |
