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Impact of 5A/6A polymorphism of matrix metalloproteinase-3 on recurrent atherosclerotic ischemic stroke in Chinese.

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Title: Impact of 5A/6A polymorphism of matrix metalloproteinase-3 on recurrent atherosclerotic ischemic stroke in Chinese.
Authors: Huang, Xiao-Ya (AUTHOR), Han, Li-Ya (AUTHOR), Huang, Xiang-Dong (AUTHOR), Guan, Chao-Hong (AUTHOR), Mao, Xin-Lei (AUTHOR), Ye, Zu-Sen (AUTHOR)
Source: International Journal of Neuroscience. Oct2016, Vol. 126 Issue 10, p936-941. 6p.
Subjects: Atherosclerosis, Stroke, Heart disease relapse, Matrix metalloproteinases, Genetic polymorphism research
Abstract: Little is known about the impact of the 5A/6A polymorphism of matrix metalloproteinase-3 (MMP-3) on recurrence of atherosclerotic ischemic stroke in Chinese. The aim of this study was to investigate the association of MMP-3 serum level and 5A/6A genetic polymorphism with the recurrence of atherosclerotic ischemic stroke in the Chinese Han population. We analyzed 106 large artery atherosclerosis (LAA) recurrent ischemic stroke patients and 545 LAA first onset ischemic stroke patients from January 2009 to June 2014. Serum MMP-3 concentrations were measured with an enzyme-linked immunosorbent assay. The genotypes of MMP-3 promoter polymorphism (−1171 5A/6A) were determined using polymerase chain reaction-restriction fragment length polymorphism. The frequencies of MMP-3 5A/6A+5A/5A (32.08% vs. 21.47%, p = 0.02) genotype and 5A (16.98% vs. 11.01%, p = 0.01) allele in the recurrent group was significantly higher than those in the first onset group. After adjustment for vascular risk factors, multivariate logistic regression analysis suggested that the MMP-3 5A/6A+5A/5A genotype was an independent risk factor for LAA recurrent ischemic stroke (odds ratio [OR], 1.74; 95% confidence interval [CI], 1.09–2.79, p = 0.021). No significant difference was observed for the MMP-3 serum concentrations between the recurrent group and the first onset group (22.23 ± 8.31 vs. 21.49 ± 7.89 ng/ul, t = 0.88, p = 0.38). The MMP-3 (−1171 5A/6A) polymorphism may contribute to LAA recurrent ischemic stroke susceptibility. Analysis of 5A/6A polymorphism in MMP-3 may identify patients at higher risk for LAA ischemic stroke recurrence, who may be selected for intensive preventive therapy. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Impact of 5A/6A polymorphism of matrix metalloproteinase-3 on recurrent atherosclerotic ischemic stroke in Chinese.
– Name: Author
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  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Huang%2C+Xiao-Ya%22">Huang, Xiao-Ya</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Han%2C+Li-Ya%22">Han, Li-Ya</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Xiang-Dong%22">Huang, Xiang-Dong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guan%2C+Chao-Hong%22">Guan, Chao-Hong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mao%2C+Xin-Lei%22">Mao, Xin-Lei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ye%2C+Zu-Sen%22">Ye, Zu-Sen</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Oct2016, Vol. 126 Issue 10, p936-941. 6p.
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  Data: <searchLink fieldCode="DE" term="%22Atherosclerosis%22">Atherosclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Stroke%22">Stroke</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+disease+relapse%22">Heart disease relapse</searchLink><br /><searchLink fieldCode="DE" term="%22Matrix+metalloproteinases%22">Matrix metalloproteinases</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphism+research%22">Genetic polymorphism research</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Little is known about the impact of the 5A/6A polymorphism of matrix metalloproteinase-3 (MMP-3) on recurrence of atherosclerotic ischemic stroke in Chinese. The aim of this study was to investigate the association of MMP-3 serum level and 5A/6A genetic polymorphism with the recurrence of atherosclerotic ischemic stroke in the Chinese Han population. We analyzed 106 large artery atherosclerosis (LAA) recurrent ischemic stroke patients and 545 LAA first onset ischemic stroke patients from January 2009 to June 2014. Serum MMP-3 concentrations were measured with an enzyme-linked immunosorbent assay. The genotypes of MMP-3 promoter polymorphism (−1171 5A/6A) were determined using polymerase chain reaction-restriction fragment length polymorphism. The frequencies of MMP-3 5A/6A+5A/5A (32.08% vs. 21.47%, p = 0.02) genotype and 5A (16.98% vs. 11.01%, p = 0.01) allele in the recurrent group was significantly higher than those in the first onset group. After adjustment for vascular risk factors, multivariate logistic regression analysis suggested that the MMP-3 5A/6A+5A/5A genotype was an independent risk factor for LAA recurrent ischemic stroke (odds ratio [OR], 1.74; 95% confidence interval [CI], 1.09–2.79, p = 0.021). No significant difference was observed for the MMP-3 serum concentrations between the recurrent group and the first onset group (22.23 ± 8.31 vs. 21.49 ± 7.89 ng/ul, t = 0.88, p = 0.38). The MMP-3 (−1171 5A/6A) polymorphism may contribute to LAA recurrent ischemic stroke susceptibility. Analysis of 5A/6A polymorphism in MMP-3 may identify patients at higher risk for LAA ischemic stroke recurrence, who may be selected for intensive preventive therapy. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.3109/00207454.2015.1088013
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      – Code: eng
        Text: English
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        PageCount: 6
        StartPage: 936
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      – SubjectFull: Atherosclerosis
        Type: general
      – SubjectFull: Stroke
        Type: general
      – SubjectFull: Heart disease relapse
        Type: general
      – SubjectFull: Matrix metalloproteinases
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      – SubjectFull: Genetic polymorphism research
        Type: general
    Titles:
      – TitleFull: Impact of 5A/6A polymorphism of matrix metalloproteinase-3 on recurrent atherosclerotic ischemic stroke in Chinese.
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            NameFull: Huang, Xiao-Ya
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            NameFull: Han, Li-Ya
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            NameFull: Huang, Xiang-Dong
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            NameFull: Guan, Chao-Hong
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            NameFull: Mao, Xin-Lei
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            NameFull: Ye, Zu-Sen
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              M: 10
              Text: Oct2016
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