Bibliographic Details
| Title: |
Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity. |
| Authors: |
Wright, Tom H., Bower, Ben J., Chalker, Justin M., Bernardes, Gonçalo J. L., Wiewiora, Rafal, Wai-Lung Ng, Raj, Ritu, Faulkner, Sarah, J. Vallée, M. Robert, Phanumartwiwath, Anuchit, Coleman, Oliver D., Thézénas, Marie-Laëtitia, Khan, Maola, Galan, Sébastien R. G., Lercher, Lukas, Schombs, Matthew W., Gerstberger, Stefanie, Palm-Espling, Maria E., Baldwin, Andrew J., Kessler, Benedikt M. |
| Source: |
Science (pre-March 2025). 11/4/2016, Vol. 354 Issue 6312, p597-597. 1p. 1 Diagram. |
| Subjects: |
Chemical modification of proteins, Chemical mutagenesis, Carbon-carbon bonds, Amino acids, Bond formation mechanism |
| Abstract: |
The article discusses research which investigated the posttranslational chemical mutagenesis of a protein using carbon-carbon bond formation. Topics discussed include the chemical editing of amino acid residue dehydroalanine (Dha), the selective reaction of radicals with Dha in peptides and proteins, and the creation of many protein side chains. |
| Database: |
Psychology and Behavioral Sciences Collection |
