Altered serum level of matrix metalloproteinase-9 and its association with decision-making in eating disorders.
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| Title: | Altered serum level of matrix metalloproteinase-9 and its association with decision-making in eating disorders. |
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| Authors: | Matsumoto, Junko, Hirano, Yoshiyuki, Hashimoto, Kenji, Ishima, Tamaki, Kanahara, Nobuhisa, Niitsu, Tomihisa, Shiina, Akihiro, Hashimoto, Tasuku, Sato, Yasunori, Yokote, Koutaro, Murano, Shunichi, Kimura, Hiroshi, Hosoda, Yutaka, Shimizu, Eiji, Iyo, Masaomi, Nakazato, Michiko |
| Source: | Psychiatry & Clinical Neurosciences. Feb2017, Vol. 71 Issue 2, p124-134. 11p. |
| Subjects: | Anorexia nervosa, Brain-derived neurotrophic factor, Bulimia, Matrix metalloproteinases, Eating disorders |
| Abstract: | Aim The aims of this study were to determine whether the serum levels of precursor brain-derived neurotrophic factor (pro BDNF), mature BDNF (m BDNF), and matrix metalloproteinase-9 ( MMP-9) are altered in patients with eating disorders ( ED), including anorexia nervosa ( AN) and bulimia nervosa ( BN), and to explore whether those levels are associated with decision-making abilities. Methods Nineteen women with AN, 28 women with BN, and 22 age-matched healthy control women ( HC) were enrolled in the current study. All participants had their decision-making abilities assessed using the Iowa Gambling Task ( IGT). Their eating-related pathophysiology and depressive/anxiety symptoms were also evaluated. Results The MMP-9 level in AN was significantly lower than that in either BN or HC, but the serum levels of pro BDNF and m BDNF did not differ among the three groups. Investigation of the serum levels of pro BDNF and MMP-9 in patients with ED and controls revealed a significant correlation between them. In the BN, there were positive correlations between m BDNF level and IGT performance and also between MMP-9 level and IGT performance, but these correlations did not occur in AN. The MMP-9 level was positively associated with the Symptom Scale, one of the subscales of the Bulimic Investigatory Test, Edinburgh, only in AN. Conclusion These results suggest that the serum level of MMP-9 plays a role in the pathophysiology of AN, and both the serum levels of m BDNF and MMP-9 may be associated with decision-making abilities in patients with BN. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Aim The aims of this study were to determine whether the serum levels of precursor brain-derived neurotrophic factor (pro BDNF), mature BDNF (m BDNF), and matrix metalloproteinase-9 ( MMP-9) are altered in patients with eating disorders ( ED), including anorexia nervosa ( AN) and bulimia nervosa ( BN), and to explore whether those levels are associated with decision-making abilities. Methods Nineteen women with AN, 28 women with BN, and 22 age-matched healthy control women ( HC) were enrolled in the current study. All participants had their decision-making abilities assessed using the Iowa Gambling Task ( IGT). Their eating-related pathophysiology and depressive/anxiety symptoms were also evaluated. Results The MMP-9 level in AN was significantly lower than that in either BN or HC, but the serum levels of pro BDNF and m BDNF did not differ among the three groups. Investigation of the serum levels of pro BDNF and MMP-9 in patients with ED and controls revealed a significant correlation between them. In the BN, there were positive correlations between m BDNF level and IGT performance and also between MMP-9 level and IGT performance, but these correlations did not occur in AN. The MMP-9 level was positively associated with the Symptom Scale, one of the subscales of the Bulimic Investigatory Test, Edinburgh, only in AN. Conclusion These results suggest that the serum level of MMP-9 plays a role in the pathophysiology of AN, and both the serum levels of m BDNF and MMP-9 may be associated with decision-making abilities in patients with BN. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 13231316 |
| DOI: | 10.1111/pcn.12490 |
