View in EDS PDF Full Text

Diarrhoea in children: an interface between developing and developed countries.

Saved in:
Bibliographic Details
Title: Diarrhoea in children: an interface between developing and developed countries.
Source: Lancet. 2/21/2004, Vol. 363 Issue 9409, p641-653. 13p.
Subjects: Diarrhea in children, Pediatric gastroenterology, Diarrhea in infants, Child mortality, Malnutrition, Vaccination, Preventive medicine, Fluid therapy, Pathogenic microorganisms, Contamination of drinking water
Abstract: Despite much progress in the understanding of pathogenesis and of management, diarrhoeal illnesses remain one of the most important causes of global childhood mortality and morbidity. Infections account for most illnesses, with pathogens employing ingenious mechanisms to establish disease. In the developed world, an upsurge in immunemediated gut disorders might have resulted from a disruption of normal bacterial-epithelial cross-talk and impaired maturation of the gut's immune system. Oral rehydration therapies are the mainstay of management of gastroenteritis, and their composition continues to improve. Malnutrition remains the major adverse prognostic indicator for diarrhoearelated mortality, emphasising the importance of nutrition in early management. Drugs are of little use, except for specific indications although new agents that target mechanisms of secretory diarrhoea show promise, as do probiotics. However, preventive strategies on a global scale might ultimately hold the greatest potential to reduce the burden of diarrhoeal disease. These strategies include vaccines and, most importantly, policies to address persisting inequalities between the developed and developing worlds with respect to nutrition, sanitation, and access to safe drinking water. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 12324526
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Diarrhoea in children: an interface between developing and developed countries.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 2/21/2004, Vol. 363 Issue 9409, p641-653. 13p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Diarrhea+in+children%22">Diarrhea in children</searchLink><br /><searchLink fieldCode="DE" term="%22Pediatric+gastroenterology%22">Pediatric gastroenterology</searchLink><br /><searchLink fieldCode="DE" term="%22Diarrhea+in+infants%22">Diarrhea in infants</searchLink><br /><searchLink fieldCode="DE" term="%22Child+mortality%22">Child mortality</searchLink><br /><searchLink fieldCode="DE" term="%22Malnutrition%22">Malnutrition</searchLink><br /><searchLink fieldCode="DE" term="%22Vaccination%22">Vaccination</searchLink><br /><searchLink fieldCode="DE" term="%22Preventive+medicine%22">Preventive medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Fluid+therapy%22">Fluid therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Pathogenic+microorganisms%22">Pathogenic microorganisms</searchLink><br /><searchLink fieldCode="DE" term="%22Contamination+of+drinking+water%22">Contamination of drinking water</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Despite much progress in the understanding of pathogenesis and of management, diarrhoeal illnesses remain one of the most important causes of global childhood mortality and morbidity. Infections account for most illnesses, with pathogens employing ingenious mechanisms to establish disease. In the developed world, an upsurge in immunemediated gut disorders might have resulted from a disruption of normal bacterial-epithelial cross-talk and impaired maturation of the gut's immune system. Oral rehydration therapies are the mainstay of management of gastroenteritis, and their composition continues to improve. Malnutrition remains the major adverse prognostic indicator for diarrhoearelated mortality, emphasising the importance of nutrition in early management. Drugs are of little use, except for specific indications although new agents that target mechanisms of secretory diarrhoea show promise, as do probiotics. However, preventive strategies on a global scale might ultimately hold the greatest potential to reduce the burden of diarrhoeal disease. These strategies include vaccines and, most importantly, policies to address persisting inequalities between the developed and developing worlds with respect to nutrition, sanitation, and access to safe drinking water. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=12324526
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/S0140-6736(04)15599-2
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 13
        StartPage: 641
    Subjects:
      – SubjectFull: Diarrhea in children
        Type: general
      – SubjectFull: Pediatric gastroenterology
        Type: general
      – SubjectFull: Diarrhea in infants
        Type: general
      – SubjectFull: Child mortality
        Type: general
      – SubjectFull: Malnutrition
        Type: general
      – SubjectFull: Vaccination
        Type: general
      – SubjectFull: Preventive medicine
        Type: general
      – SubjectFull: Fluid therapy
        Type: general
      – SubjectFull: Pathogenic microorganisms
        Type: general
      – SubjectFull: Contamination of drinking water
        Type: general
    Titles:
      – TitleFull: Diarrhoea in children: an interface between developing and developed countries.
        Type: main
  BibRelationships:
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 21
              M: 02
              Text: 2/21/2004
              Type: published
              Y: 2004
          Identifiers:
            – Type: issn-print
              Value: 01406736
          Numbering:
            – Type: volume
              Value: 363
            – Type: issue
              Value: 9409
          Titles:
            – TitleFull: Lancet
              Type: main
ResultId 1