Persistent increase in TNF and IL-1 markers in severe mental disorders suggests trait-related inflammation: a one year follow-up study.
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| Title: | Persistent increase in TNF and IL-1 markers in severe mental disorders suggests trait-related inflammation: a one year follow-up study. |
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| Authors: | Mørch, R. H., Dieset, I., Færden, A., Hope, S., Aas, M., Nerhus, M., Gardsjord, E. S., Haram, M., Falk, R. S., Joa, I., Morken, G., Agartz, I., Aukrust, P., Djurovic, S., Melle, I., Ueland, T., Andreassen, O. A. |
| Source: | Acta Psychiatrica Scandinavica. Oct2017, Vol. 136 Issue 4, p400-408. 9p. 4 Charts, 1 Graph. |
| Subjects: | Mental illness treatment, People with mental illness, Inflammation, Blood plasma, Psychoses |
| Abstract: | Objective We evaluated if plasma levels of inflammatory markers are persistently altered in severe mental disorders with psychotic symptoms or associated with state characteristics in a longitudinal study. Methods Soluble tumor necrosis factor receptor 1 ( sTNF-R1), interleukin-1 receptor antagonist ( IL-1Ra), von Willebrand factor ( VWF), and osteoprotegerin ( OPG) were measured in schizophrenia ( n = 69) and affective ( n = 55) spectrum patients at baseline and at one-year follow-up, and compared to healthy controls ( HC) ( n = 92) with analysis of covariance. Association between change in symptoms and inflammatory markers was analyzed with mixed-effects models. Results sTNF-R1 was higher in the schizophrenia ( P < 0.0001) and affective disorders ( P = 0.02) compared to HC, while IL-1Ra was higher in schizophrenia ( P = 0.01) compared to HC at one year follow-up. There were no significant differences between schizophrenia and affective groups; however, levels in the affective group were in between schizophrenia and HC for sTNF-R1 and IL-1Ra. There were no significant associations between change in symptoms and inflammatory markers. Conclusion Persistently increased sTNF-R1 and IL-1Ra after one year in patients with severe mental disorders primarily reflecting data from the schizophrenia group may suggest that inflammation is a trait phenomenon, and not only the result of stress-related mechanisms associated with acute episodes. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Objective We evaluated if plasma levels of inflammatory markers are persistently altered in severe mental disorders with psychotic symptoms or associated with state characteristics in a longitudinal study. Methods Soluble tumor necrosis factor receptor 1 ( sTNF-R1), interleukin-1 receptor antagonist ( IL-1Ra), von Willebrand factor ( VWF), and osteoprotegerin ( OPG) were measured in schizophrenia ( n = 69) and affective ( n = 55) spectrum patients at baseline and at one-year follow-up, and compared to healthy controls ( HC) ( n = 92) with analysis of covariance. Association between change in symptoms and inflammatory markers was analyzed with mixed-effects models. Results sTNF-R1 was higher in the schizophrenia ( P < 0.0001) and affective disorders ( P = 0.02) compared to HC, while IL-1Ra was higher in schizophrenia ( P = 0.01) compared to HC at one year follow-up. There were no significant differences between schizophrenia and affective groups; however, levels in the affective group were in between schizophrenia and HC for sTNF-R1 and IL-1Ra. There were no significant associations between change in symptoms and inflammatory markers. Conclusion Persistently increased sTNF-R1 and IL-1Ra after one year in patients with severe mental disorders primarily reflecting data from the schizophrenia group may suggest that inflammation is a trait phenomenon, and not only the result of stress-related mechanisms associated with acute episodes. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 0001690X |
| DOI: | 10.1111/acps.12783 |
