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Persistent increase in TNF and IL-1 markers in severe mental disorders suggests trait-related inflammation: a one year follow-up study.

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Title: Persistent increase in TNF and IL-1 markers in severe mental disorders suggests trait-related inflammation: a one year follow-up study.
Authors: Mørch, R. H., Dieset, I., Færden, A., Hope, S., Aas, M., Nerhus, M., Gardsjord, E. S., Haram, M., Falk, R. S., Joa, I., Morken, G., Agartz, I., Aukrust, P., Djurovic, S., Melle, I., Ueland, T., Andreassen, O. A.
Source: Acta Psychiatrica Scandinavica. Oct2017, Vol. 136 Issue 4, p400-408. 9p. 4 Charts, 1 Graph.
Subjects: Mental illness treatment, People with mental illness, Inflammation, Blood plasma, Psychoses
Abstract: Objective We evaluated if plasma levels of inflammatory markers are persistently altered in severe mental disorders with psychotic symptoms or associated with state characteristics in a longitudinal study. Methods Soluble tumor necrosis factor receptor 1 ( sTNF-R1), interleukin-1 receptor antagonist ( IL-1Ra), von Willebrand factor ( VWF), and osteoprotegerin ( OPG) were measured in schizophrenia ( n = 69) and affective ( n = 55) spectrum patients at baseline and at one-year follow-up, and compared to healthy controls ( HC) ( n = 92) with analysis of covariance. Association between change in symptoms and inflammatory markers was analyzed with mixed-effects models. Results sTNF-R1 was higher in the schizophrenia ( P < 0.0001) and affective disorders ( P = 0.02) compared to HC, while IL-1Ra was higher in schizophrenia ( P = 0.01) compared to HC at one year follow-up. There were no significant differences between schizophrenia and affective groups; however, levels in the affective group were in between schizophrenia and HC for sTNF-R1 and IL-1Ra. There were no significant associations between change in symptoms and inflammatory markers. Conclusion Persistently increased sTNF-R1 and IL-1Ra after one year in patients with severe mental disorders primarily reflecting data from the schizophrenia group may suggest that inflammation is a trait phenomenon, and not only the result of stress-related mechanisms associated with acute episodes. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Persistent increase in TNF and IL-1 markers in severe mental disorders suggests trait-related inflammation: a one year follow-up study.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22M&#248;rch%2C+R%2E+H%2E%22&quot;&gt;M&#248;rch, R. H.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Dieset%2C+I%2E%22&quot;&gt;Dieset, I.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22F&#230;rden%2C+A%2E%22&quot;&gt;F&#230;rden, A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hope%2C+S%2E%22&quot;&gt;Hope, S.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Aas%2C+M%2E%22&quot;&gt;Aas, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nerhus%2C+M%2E%22&quot;&gt;Nerhus, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gardsjord%2C+E%2E+S%2E%22&quot;&gt;Gardsjord, E. S.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Haram%2C+M%2E%22&quot;&gt;Haram, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Falk%2C+R%2E+S%2E%22&quot;&gt;Falk, R. S.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Joa%2C+I%2E%22&quot;&gt;Joa, I.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Morken%2C+G%2E%22&quot;&gt;Morken, G.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Agartz%2C+I%2E%22&quot;&gt;Agartz, I.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Aukrust%2C+P%2E%22&quot;&gt;Aukrust, P.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Djurovic%2C+S%2E%22&quot;&gt;Djurovic, S.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Melle%2C+I%2E%22&quot;&gt;Melle, I.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ueland%2C+T%2E%22&quot;&gt;Ueland, T.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Andreassen%2C+O%2E+A%2E%22&quot;&gt;Andreassen, O. A.&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Acta+Psychiatrica+Scandinavica%22&quot;&gt;Acta Psychiatrica Scandinavica&lt;/searchLink&gt;. Oct2017, Vol. 136 Issue 4, p400-408. 9p. 4 Charts, 1 Graph.
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  Data: Objective We evaluated if plasma levels of inflammatory markers are persistently altered in severe mental disorders with psychotic symptoms or associated with state characteristics in a longitudinal study. Methods Soluble tumor necrosis factor receptor 1 ( sTNF-R1), interleukin-1 receptor antagonist ( IL-1Ra), von Willebrand factor ( VWF), and osteoprotegerin ( OPG) were measured in schizophrenia ( n = 69) and affective ( n = 55) spectrum patients at baseline and at one-year follow-up, and compared to healthy controls ( HC) ( n = 92) with analysis of covariance. Association between change in symptoms and inflammatory markers was analyzed with mixed-effects models. Results sTNF-R1 was higher in the schizophrenia ( P &lt; 0.0001) and affective disorders ( P = 0.02) compared to HC, while IL-1Ra was higher in schizophrenia ( P = 0.01) compared to HC at one year follow-up. There were no significant differences between schizophrenia and affective groups; however, levels in the affective group were in between schizophrenia and HC for sTNF-R1 and IL-1Ra. There were no significant associations between change in symptoms and inflammatory markers. Conclusion Persistently increased sTNF-R1 and IL-1Ra after one year in patients with severe mental disorders primarily reflecting data from the schizophrenia group may suggest that inflammation is a trait phenomenon, and not only the result of stress-related mechanisms associated with acute episodes. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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