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Inhibitory Effect of Spirodela polyrhixa on the Secretion of NO in LPS-stimulated Macrophages.

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Title: Inhibitory Effect of Spirodela polyrhixa on the Secretion of NO in LPS-stimulated Macrophages.
Authors: Woo Shin Ko, Young Hee Kim, Jung Won Yoon, So Woon Yoon, Han Do Kim
Source: American Journal of Chinese Medicine. 2004, Vol. 32 Issue 1, p65-73. 9p. 1 Diagram, 2 Graphs.
Subjects: Spirodela, Duckweeds, Spirodela polyrrhiza, Nitrogen compounds, Amic acids
Abstract: Spirodela polyrhixa Schleid has been used in folk medicine to treat inflammatory diseases. Since nitric oxide (NO) is one of the major inflammatory parameters, we studied the effect of aqueous extracts of Spirodela polyrhixa (AESP) on NO production in lipopolysaccharide (LPS)-stimulated mouse peritoneal macrophages. AESP inhibited the secretion of NO in macrophages, without affecting cell viability. The protein level of inducible nitric oxide synthase (iNOS) in peritoneal macrophages was also decreased by AESP. Transient transfection assay of reporter plasmid and gel shift assay indicated that AESP blocked the activation of nuclear factor-kappa B (NF-κB), which was considered to be a potential transcription factor for iNOS expression. AESP also blocked the phosphorylation and degradation of inhibitory protein I kappa B-alpha (IκB-α). These results suggest that AESP could exert its anti-inflammatory actions by suppressing the synthesis of NO through inhibition of NF-κB activity. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Inhibitory Effect of Spirodela polyrhixa on the Secretion of NO in LPS-stimulated Macrophages.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Woo+Shin+Ko%22">Woo Shin Ko</searchLink><br /><searchLink fieldCode="AR" term="%22Young+Hee+Kim%22">Young Hee Kim</searchLink><br /><searchLink fieldCode="AR" term="%22Jung+Won+Yoon%22">Jung Won Yoon</searchLink><br /><searchLink fieldCode="AR" term="%22So+Woon+Yoon%22">So Woon Yoon</searchLink><br /><searchLink fieldCode="AR" term="%22Han+Do+Kim%22">Han Do Kim</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Chinese+Medicine%22">American Journal of Chinese Medicine</searchLink>. 2004, Vol. 32 Issue 1, p65-73. 9p. 1 Diagram, 2 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Spirodela%22">Spirodela</searchLink><br /><searchLink fieldCode="DE" term="%22Duckweeds%22">Duckweeds</searchLink><br /><searchLink fieldCode="DE" term="%22Spirodela+polyrrhiza%22">Spirodela polyrrhiza</searchLink><br /><searchLink fieldCode="DE" term="%22Nitrogen+compounds%22">Nitrogen compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Amic+acids%22">Amic acids</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Spirodela polyrhixa Schleid has been used in folk medicine to treat inflammatory diseases. Since nitric oxide (NO) is one of the major inflammatory parameters, we studied the effect of aqueous extracts of Spirodela polyrhixa (AESP) on NO production in lipopolysaccharide (LPS)-stimulated mouse peritoneal macrophages. AESP inhibited the secretion of NO in macrophages, without affecting cell viability. The protein level of inducible nitric oxide synthase (iNOS) in peritoneal macrophages was also decreased by AESP. Transient transfection assay of reporter plasmid and gel shift assay indicated that AESP blocked the activation of nuclear factor-kappa B (NF-κB), which was considered to be a potential transcription factor for iNOS expression. AESP also blocked the phosphorylation and degradation of inhibitory protein I kappa B-alpha (IκB-α). These results suggest that AESP could exert its anti-inflammatory actions by suppressing the synthesis of NO through inhibition of NF-κB activity. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1142/S0192415X04001795
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      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 65
    Subjects:
      – SubjectFull: Spirodela
        Type: general
      – SubjectFull: Duckweeds
        Type: general
      – SubjectFull: Spirodela polyrrhiza
        Type: general
      – SubjectFull: Nitrogen compounds
        Type: general
      – SubjectFull: Amic acids
        Type: general
    Titles:
      – TitleFull: Inhibitory Effect of Spirodela polyrhixa on the Secretion of NO in LPS-stimulated Macrophages.
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          Name:
            NameFull: Woo Shin Ko
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            NameFull: Young Hee Kim
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            NameFull: Jung Won Yoon
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          Name:
            NameFull: So Woon Yoon
      – PersonEntity:
          Name:
            NameFull: Han Do Kim
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            – D: 01
              M: 01
              Text: 2004
              Type: published
              Y: 2004
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              Value: 32
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            – TitleFull: American Journal of Chinese Medicine
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