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Beyond pharmacological treatment: an insight into therapies that target specific aspects of heart failure pathophysiology.

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Title: Beyond pharmacological treatment: an insight into therapies that target specific aspects of heart failure pathophysiology.
Authors: Normand, Camilla, Kaye, David M., Povsic, Thomas J., Dickstein, Kenneth
Source: Lancet. 3/9/2019, Vol. 393 Issue 10175, p1045-1055. 11p.
Subjects: Arrhythmia, Heart failure, Implantable cardioverter-defibrillators, Pathological physiology, Cellular therapy, Myocardium, Heart failure treatment, Cardiac catheterization, Cardiac pacing, Guided tissue regeneration, Sympathetic nervous system, Vagus nerve
Abstract: Heart failure is a common syndrome associated with substantial morbidity and mortality. The management of symptoms and the strategies for improving prognosis have largely been based on pharmacological treatments. The pathophysiology of heart failure is complex because of the multiple causes responsible for this syndrome. This Series paper presents some examples of advances in heart failure management, in which the treatment specifically targets the underlying pathophysiological mechanisms responsible for the symptoms. These treatments include treatment of electromechanical dyssynchrony and dysrhythmia by cardiac resynchronisation and implantable cardioverter-defibrillators; neurohumoral modification by baroreflex and vagal stimulation; prevention of adverse cardiac remodelling by interatrial shunts; and finally targeting the myocardium directly by cell therapy in an attempt to regenerate new myocardial cells. [ABSTRACT FROM AUTHOR]
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Database: Psychology and Behavioral Sciences Collection
Description
Abstract:Heart failure is a common syndrome associated with substantial morbidity and mortality. The management of symptoms and the strategies for improving prognosis have largely been based on pharmacological treatments. The pathophysiology of heart failure is complex because of the multiple causes responsible for this syndrome. This Series paper presents some examples of advances in heart failure management, in which the treatment specifically targets the underlying pathophysiological mechanisms responsible for the symptoms. These treatments include treatment of electromechanical dyssynchrony and dysrhythmia by cardiac resynchronisation and implantable cardioverter-defibrillators; neurohumoral modification by baroreflex and vagal stimulation; prevention of adverse cardiac remodelling by interatrial shunts; and finally targeting the myocardium directly by cell therapy in an attempt to regenerate new myocardial cells. [ABSTRACT FROM AUTHOR]
ISSN:01406736
DOI:10.1016/S0140-6736(18)32216-5