KRAS mutations in tongue squamous cell carcinoma.
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| Title: | KRAS mutations in tongue squamous cell carcinoma. |
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| Authors: | Akagi, Yusuke (AUTHOR), Tachibana, Tomoyasu (AUTHOR), Orita, Yorihisa (AUTHOR), Gion, Yuka (AUTHOR), Marunaka, Hidenori (AUTHOR), Makino, Takuma (AUTHOR), Miki, Kentaro (AUTHOR), Akisada, Naoki (AUTHOR), Yoshino, Tadashi (AUTHOR), Nishizaki, Kazunori (AUTHOR), Sato, Yasuharu (AUTHOR) |
| Source: | Acta Oto-Laryngologica. Jul2019, Vol. 139 Issue 7, p647-651. 5p. |
| Subjects: | Squamous cell carcinoma, Gene expression, Lung tumors, Metastasis, Genetic mutation, Oncogenes, Stains & staining (Microscopy), Tongue tumors, Prognosis |
| Abstract (English): | Background: p16INK4a (p16) expression in tongue cancer (TC) is reportedly not associated with human papilloma virus (HPV). Mutations of KRAS in cancer cells are most frequently observed within codon 12. However, few reports have investigated the association between KRAS mutations and p16 status in TC. Objectives: This study aimed to evaluate the influence of KRAS mutations on TC. Methods: Clinical records and surgically resected specimens of 85 TC patients were analyzed. Tumor samples were analyzed for mutations of KRAS located within codons 12 and 13. p16 staining was performed and considered positive in cases with moderate to strong nuclear and cytoplasmic staining. Results: Positive p16 staining was observed in 10 cases (11.8%). A KRAS mutation was detected in one case (1.2%). The case with KRAS mutation showed negative p16 staining. Despite being at an early stage, the patient died of lung metastasis at 43 months from initial treatment. Conclusions and Significance:KRAS mutations are not associated with p16 expression in TC and may predict poor prognosis in TC patients. Further analysis of mutations in regions other than codons 12 and 13 of KRAS will be necessary to determine the relationship between KRAS mutations and prognosis of this disease. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): | 背景：据报道, 舌癌（TC）的p16 INK4a （p16）表达与人乳头状瘤病毒（HPV）无关。癌细胞中KRAS突变最常见于密码子12。然而, 很少有报道研究KRAS突变与TC中p16状态之间的关系。 目的：本研究旨在评价KRAS突变对TC的影响。 方法：对85例TC患者的临床资料和手术切除标本进行分析。分析肿瘤样本中位于密码子12和13内的KRAS突变。进行了p16染色, 细胞核和细胞质染色呈中强度, 则被认为是阳性的。 结果：10例患者（11.8%）p16染色阳性。1例（1.2%）检测到KRAS突变。KRAS突变病例的p16染色呈阴性。尽管处于早期阶段, 但患者在最初治疗后43个月死于肺转移。 结论和意义：KRAS突变与TC患者的p16表达无关, 可能预测TC患者预后不良。为了确定KRAS突变与该病预后之间的关系, 有必要对KRAS密码子12和13以外的区域的突变进行进一步分析。 [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Background: p16INK4a (p16) expression in tongue cancer (TC) is reportedly not associated with human papilloma virus (HPV). Mutations of KRAS in cancer cells are most frequently observed within codon 12. However, few reports have investigated the association between KRAS mutations and p16 status in TC. Objectives: This study aimed to evaluate the influence of KRAS mutations on TC. Methods: Clinical records and surgically resected specimens of 85 TC patients were analyzed. Tumor samples were analyzed for mutations of KRAS located within codons 12 and 13. p16 staining was performed and considered positive in cases with moderate to strong nuclear and cytoplasmic staining. Results: Positive p16 staining was observed in 10 cases (11.8%). A KRAS mutation was detected in one case (1.2%). The case with KRAS mutation showed negative p16 staining. Despite being at an early stage, the patient died of lung metastasis at 43 months from initial treatment. Conclusions and Significance:KRAS mutations are not associated with p16 expression in TC and may predict poor prognosis in TC patients. Further analysis of mutations in regions other than codons 12 and 13 of KRAS will be necessary to determine the relationship between KRAS mutations and prognosis of this disease. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00016489 |
| DOI: | 10.1080/00016489.2019.1610574 |
